miRNA General Information
miRNA Mature ID hsa-miR-558
miRNA Stemloop AC MI0003564
miRNA Stemloop ID hsa-mir-558
Sequence ugagcugcuguaccaaaau
TTD Target(s) Regulated by This miRNA Heparanase (HPSE) Successful Target Target Info [1]
Prostaglandin G/H synthase 2 (COX-2) Successful Target Target Info [2]
Protein(s) Regulated by This miRNA Serine/threonine-protein kinase LMTK1 Regulated Protein [3]
References
REF 1 miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expression. Cell Death Dis. 2016 Sep 29;7(9):e2382.
REF 2 MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1-induced catabolic effects in human articular chondrocytes. Osteoarthritis Cartilage. 2013 Jul;21(7):981-9.
REF 3 Downregulation of AATK mediates microRNA-558-induced resistance of A549 cells to radiotherapy.Mol Med Rep. 2016 Sep;14(3):2846-52.

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