miRNA General Information
miRNA Mature ID hsa-miR-542-3p
miRNA Stemloop AC MI0003686
miRNA Stemloop ID hsa-mir-542
Sequence ugugacagauugauaacugaaa
TTD Target(s) Regulated by This miRNA RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Target Info [1]
Angiopoietin-2 (ANGPT2) Successful Target Target Info [2]
Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Target Info [3]
Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target Target Info [4]
Frizzled-7 receptor (FZD7) Clinical trial Target Target Info [5]
Integrin-linked protein kinase 1 (ILK) Patented-recorded Target Target Info [1]
Insulin-like growth factor-binding protein 1 (IGFBP1) Literature-reported Target Target Info [6]
Metastasis adhesion protein (MTDH) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA 40S ribosomal protein S23 Regulated Protein [8]
Bone morphogenetic protein 7 Regulated Protein [9]
Phosphatidylinositol 3-kinase regulatory subunit alpha Regulated Protein [1]
Src substrate cortactin Regulated Protein [11]
Ubiquitin thioesterase OTUB1 Regulated Protein [12]
References
REF 1 MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma. J Biol Chem. 2015 Oct 9;290(41):24678-88.
REF 2 MicroRNA-542-3p inhibits tumour angiogenesis by targeting angiopoietin-2. J Pathol. 2014 Apr;232(5):499-508.
REF 3 Induction of growth arrest by miR-542-3p that targets survivin. FEBS Lett. 2010 Sep 24;584(18):4048-52.
REF 4 miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma. Biochem Biophys Res Commun. 2016 May 27;474(2):315-320.
REF 5 MicroRNA-542-3p inhibits the growth of hepatocellular carcinoma cells by targeting FZD7/Wnt signaling pathway. Biochem Biophys Res Commun. 2017 Jan 1;482(1):100-105.
REF 6 Loss of miR-542-3p enhances IGFBP-1 expression in decidualizing human endometrial stromal cells. Sci Rep. 2017 Jan 4;7:40001.
REF 7 MicroRNA-542-3p suppresses cell growth of gastric cancer cells via targeting oncogene astrocyte-elevated gene-1. Med Oncol. 2015 Jan;32(1):361.
REF 8 p53 is positively regulated by miR-542-3p.Cancer Res. 2014 Jun 15;74(12):3218-27.
REF 9 miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation.Cell Death Dis. 2014 Feb 6;5:e1050.
REF 10 MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma. J Biol Chem. 2015 Oct 9;290(41):24678-88.
REF 11 miR-542-3p inhibits the growth and invasion of colorectal cancer cells through targeted regulation of cortactin.Int J Mol Med. 2016 Apr;37(4):1112-8.
REF 12 miR-542-3p inhibits colorectal cancer cell proliferation, migration and invasion by targeting OTUB1. Am J Cancer Res. 2017 Jan 1;7(1):159-172.

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