miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-539-5p | ||||
miRNA Stemloop AC | MI0003514 | ||||
miRNA Stemloop ID | hsa-mir-539 | ||||
Sequence | ggagaaauuauccuuggugugu | ||||
TTD Target(s) Regulated by This miRNA | Cyclin-dependent kinase 4 (CDK4) | Successful Target | Target Info | [1] | |
Matrix metalloproteinase-8 (MMP-8) | Clinical trial Target | Target Info | [2] | ||
Protein(s) Regulated by This miRNA | Caspase recruitment domain-containing protein 11 | Regulated Protein | [3] | ||
Sperm-associated antigen 5 | Regulated Protein | [4] | |||
Twist-related protein 1 | Regulated Protein | [5] | |||
Zinc finger E-box-binding homeobox 1 | Regulated Protein | [5] | |||
References | |||||
REF 1 | miR-539 induces cell cycle arrest in nasopharyngeal carcinoma by targeting cyclin-dependent kinase 4. Cell Biochem Funct. 2015 Dec;33(8):534-40. | ||||
REF 2 | MicroRNA-539 suppresses osteosarcoma cell invasion and migration in vitro and targeting Matrix metallopeptidase-8. Int J Clin Exp Pathol. 2015 Jul 1;8(7):8075-82. | ||||
REF 3 | MiR-539 inhibits thyroid cancer cell migration and invasion by directly targeting CARMA1.Biochem Biophys Res Commun. 2015 Sep 4;464(4):1128-1133. | ||||
REF 4 | miR-539 inhibits prostate cancer progression by directly targeting SPAG5.J Exp Clin Cancer Res. 2016 Apr 1;35:60. | ||||
REF 5 | MicroRNAs in the imprinted DLK1-DIO3 region repress the epithelial-to-mesenchymal transition by targeting the TWIST1 protein signaling network. J Biol Chem. 2012 Dec 14;287(51):42695-707. |
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