miRNA General Information
miRNA Mature ID hsa-miR-520c-3p
miRNA Stemloop AC MI0003158
miRNA Stemloop ID hsa-mir-520c
Sequence aaagugcuuccuuuuagagggu
TTD Target(s) Regulated by This miRNA Serine/threonine-protein kinase mTOR (mTOR) Successful Target Target Info [1]
Amyloid beta A4 protein (APP) Successful Target Target Info [2]
Signal transducer and activator of transcription 3 (STAT3) Successful Target Target Info [3]
NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Target Info [1]
Extracellular matrix receptor III (CD44) Clinical trial Target Target Info [4]
Glypican-3 (GPC3) Clinical trial Target Target Info [5]
Protein(s) Regulated by This miRNA Eukaryotic translation initiation factor 4 gamma 1 Regulated Protein [6]
Interferon regulatory factor 2 Regulated Protein [7]
MHC class I polypeptide-related sequence A Regulated Protein [8]
References
REF 1 miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-B factor in human fibrosarcoma cells. J Cell Physiol. 2012 Feb;227(2):867-76.
REF 2 MicroRNAs can regulate human APP levels. Mol Neurodegener. 2008 Aug 6;3:10.
REF 3 miR520c blocks EMT progression of human breast cancer cells by repressing STAT3. Oncol Rep. 2017 Mar;37(3):1537-1544.
REF 4 The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol. 2008 Feb;10(2):202-10.
REF 5 MicroRNA-520c-3p inhibits hepatocellular carcinoma cell proliferation and invasion through induction of cell apoptosis by targeting glypican-3. Hepatol Res. 2014 Mar;44(3):338-48.
REF 6 Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.PLoS Genet. 2014 Jan 30;10(1):e1004105.
REF 7 MicroRNA-520c enhances cell proliferation, migration, and invasion by suppressing IRF2 in gastric cancer.FEBS Open Bio. 2016 Oct 31;6(12):1257-1266.
REF 8 Downregulation of miR-302c and miR-520c by 1,25(OH)2D3 treatment enhances the susceptibility of tumour cells to natural killer cell-mediated cytotoxicity.Br J Cancer. 2013 Aug 6;109(3):723-30.

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