miRNA General Information
miRNA Mature ID hsa-miR-448
miRNA Stemloop AC MI0001637
miRNA Stemloop ID hsa-mir-448
Sequence uugcauauguaggaugucccau
TTD Target(s) Regulated by This miRNA Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [2]
ERK activator kinase 1 (MEK1) Clinical trial Target Target Info [2]
Mammalian disintegrin-metalloprotease (ADAM10) Clinical trial Target Target Info [3]
Stromal cell-derived factor 1 (CXCL12) Clinical trial Target Target Info [4]
IP3 receptor isoform 1 (ITPR1) Literature-reported Target Target Info [2]
Protein(s) Regulated by This miRNA DNA-binding protein SATB1 Regulated Protein [5]
Lysine-specific demethylase 2B Regulated Protein [6]
Metallophosphoesterase MPPED2 Regulated Protein [7]
References
REF 1 miR-448 suppresses proliferation and invasion by regulating IGF1R in colorectal cancer cells. Am J Transl Res. 2016 Jul 15;8(7):3013-22.
REF 2 The changes of miRNA expression in rat hippocampus following chronic lead exposure. Toxicol Lett. 2014 Aug 17;229(1):158-66.
REF 3 miR-448 suppressed gastric cancer proliferation and invasion by regulating ADAM10. Tumour Biol. 2016 Aug;37(8):10545-51.
REF 4 miR-448 negatively regulates ovarian cancer cell growth and metastasis by targeting CXCL12. Clin Transl Oncol. 2015 Nov;17(11):903-9.
REF 5 Involvement of NF-B/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells.Cell Death Differ. 2011 Jan;18(1):16-25.
REF 6 MiR-448 promotes glycolytic metabolism of gastric cancer by downregulating KDM2B.Oncotarget. 2016 Apr 19;7(16):22092-102.
REF 7 miR-448 downregulates MPPED2 to promote cancer proliferation and inhibit apoptosis in oral squamous cell carcinoma. Exp Ther Med. 2016 Oct;12(4):2747-2752.

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