miRNA General Information
miRNA Mature ID hsa-miR-372-3p
miRNA Stemloop AC MI0000780
miRNA Stemloop ID hsa-mir-372
Sequence aaagugcugcgacauuugagcgu
TTD Target(s) Regulated by This miRNA Erbb4 tyrosine kinase receptor (Erbb-4) Successful Target Target Info [1]
Vascular endothelial growth factor A (VEGFA) Successful Target Target Info [2]
Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Target Info [3]
Wee1-like protein kinase (WEE1) Clinical trial Target Target Info [4]
Dickkopf-related protein 1 (DKK1) Clinical trial Target Target Info [5]
TGF-beta receptor type II (TGFBR2) Clinical trial Target Target Info [5]
Large tumor suppressor homolog 2 (LATS2) Literature-reported Target Target Info [6]
ATPase family AAA domain containing 2 (ATAD2) Literature-reported Target Target Info [7]
Orphan nuclear receptor NURR1 (NR4A2) Literature-reported Target Target Info [1]
Vitamin D3 up-regulated protein 1 (VDUP1) Literature-reported Target Target Info [8]
Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Target Info [9]
Muscleblind-like protein 1 (MBNL2) Literature-reported Target Target Info [10]
B-cell translocation gene 1 protein (BTG1) Literature-reported Target Target Info [5]
Suppressor of tumorigenicity 15 protein (ST15) Literature-reported Target Target Info [11]
Protein(s) Regulated by This miRNA BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 Regulated Protein [12]
Cyclin-A1 Regulated Protein [13]
Krueppel-like factor 13 Regulated Protein [10]
Left-right determination factor 1 Regulated Protein [5]
Nuclear factor 1 B-type Regulated Protein [16]
PH domain leucine-rich repeat-containing protein phosphatase 2 Regulated Protein [17]
Rho-related GTP-binding protein RhoC Regulated Protein [18]
Zinc finger transcription factor Trps1 Regulated Protein [10]
References
REF 1 Identification of microRNAs regulated by activin A in human embryonic stem cells. J Cell Biochem. 2010 Jan 1;109(1):93-102.
REF 2 The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 2008 Mar 5;3(3):e1719.
REF 3 CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol. 2013 Mar 18;200(6):743-56.
REF 4 microRNAs regulate human embryonic stem cell division. Cell Cycle. 2009 Nov 15;8(22):3729-41.
REF 5 -Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/-catenin-signaling pathway. Oncogene. 2012 Jun 14;31(24):2968-78.
REF 6 A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell. 2006 Mar 24;124(6):1169-81.
REF 7 miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis. BMC Cancer. 2014 Feb 19;14:107.
REF 8 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41.
REF 9 MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol. 2008 Apr;28(7):2167-74.
REF 10 Target identification of microRNAs expressed highly in human embryonic stem cells. J Cell Biochem. 2009 Apr 15;106(6):1020-30.
REF 11 MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008 Sep;28(17):5369-80.
REF 12 microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFB signaling in human gastric carcinoma cells.Int J Oncol. 2013 Feb;42(2):635-42.
REF 13 MicroRNA-372 is down-regulated and targets cyclin-dependent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contribute to tumorigenesis. J Biol Chem. 2011 Jul 22;286(29):25556-63.
REF 14 Target identification of microRNAs expressed highly in human embryonic stem cells. J Cell Biochem. 2009 Apr 15;106(6):1020-30.
REF 15 -Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/-catenin-signaling pathway. Oncogene. 2012 Jun 14;31(24):2968-78.
REF 16 MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B.Hepatology. 2011 Sep 2;54(3):808-19.
REF 17 miR-372 regulates glioma cell proliferation and invasion by directly targeting PHLPP2.J Cell Biochem. 2015 Feb;116(2):225-32.
REF 18 Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011 May;29(5):443-8.

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