miRNA General Information
miRNA Mature ID hsa-miR-34c-3p
miRNA Stemloop AC MI0000743
miRNA Stemloop ID hsa-mir-34c
Sequence aaucacuaaccacacggccagg
TTD Target(s) Regulated by This miRNA Beta-catenin (CTNNB1) Successful Target Target Info [1]
Myristoylated alanine-rich C-kinase substrate (MARCKS) Clinical trial Target Target Info [2]
Eukaryotic initiation factor 4E (EIF4E) Literature-reported Target Target Info [3]
Protein(s) Regulated by This miRNA Axin-2 Regulated Protein [1]
Lymphoid enhancer-binding factor 1 Regulated Protein [1]
Nck-associated protein 1 Regulated Protein [5]
PI-PLC X domain-containing protein 3 Regulated Protein [6]
Proteasome assembly chaperone 1 Regulated Protein [7]
References
REF 1 MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle. 2012 Apr 1;11(7):1273-81.
REF 2 miR-34c-3p inhibits cell proliferation, migration and invasion of hepatocellular carcinoma by targeting MARCKS. Int J Clin Exp Pathol. 2015 Oct 1;8(10):12728-37.
REF 3 miR-34c-3p functions as a tumour suppressor by inhibiting eIF4E expression in non-small cell lung cancer. Cell Prolif. 2015 Oct;48(5):582-92.
REF 4 MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle. 2012 Apr 1;11(7):1273-81.
REF 5 MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expression.J Cancer Res Clin Oncol. 2017 Feb;143(2):263-273.
REF 6 Integrated analysis miRNA and mRNA profiling in patients with severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3 expression.Oncotarget. 2016 Aug 16;7(33):52781-52796.
REF 7 MiR-34c-3p suppresses the proliferation and invasion of non-small cell lung cancer (NSCLC) by inhibiting PAC1/MAPK pathway. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6312-22.

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