miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-34c-3p | ||||
miRNA Stemloop AC | MI0000743 | ||||
miRNA Stemloop ID | hsa-mir-34c | ||||
Sequence | aaucacuaaccacacggccagg | ||||
TTD Target(s) Regulated by This miRNA | Beta-catenin (CTNNB1) | Successful Target | Target Info | [1] | |
Myristoylated alanine-rich C-kinase substrate (MARCKS) | Clinical trial Target | Target Info | [2] | ||
Eukaryotic initiation factor 4E (EIF4E) | Literature-reported Target | Target Info | [3] | ||
Protein(s) Regulated by This miRNA | Axin-2 | Regulated Protein | [1] | ||
Lymphoid enhancer-binding factor 1 | Regulated Protein | [1] | |||
Nck-associated protein 1 | Regulated Protein | [5] | |||
PI-PLC X domain-containing protein 3 | Regulated Protein | [6] | |||
Proteasome assembly chaperone 1 | Regulated Protein | [7] | |||
References | |||||
REF 1 | MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle. 2012 Apr 1;11(7):1273-81. | ||||
REF 2 | miR-34c-3p inhibits cell proliferation, migration and invasion of hepatocellular carcinoma by targeting MARCKS. Int J Clin Exp Pathol. 2015 Oct 1;8(10):12728-37. | ||||
REF 3 | miR-34c-3p functions as a tumour suppressor by inhibiting eIF4E expression in non-small cell lung cancer. Cell Prolif. 2015 Oct;48(5):582-92. | ||||
REF 4 | MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle. 2012 Apr 1;11(7):1273-81. | ||||
REF 5 | MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expression.J Cancer Res Clin Oncol. 2017 Feb;143(2):263-273. | ||||
REF 6 | Integrated analysis miRNA and mRNA profiling in patients with severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3 expression.Oncotarget. 2016 Aug 16;7(33):52781-52796. | ||||
REF 7 | MiR-34c-3p suppresses the proliferation and invasion of non-small cell lung cancer (NSCLC) by inhibiting PAC1/MAPK pathway. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6312-22. |
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