miRNA General Information
miRNA Mature ID hsa-miR-29b-1-5p
miRNA Stemloop AC MI0000105
miRNA Stemloop ID hsa-mir-29b-1
Sequence gcugguuucauauggugguuuaga
TTD Target(s) Regulated by This miRNA Janus kinase 3 (JAK-3) Successful Target Target Info [1]
Signal transducer and activator of transcription 3 (STAT3) Successful Target Target Info [2]
Transforming growth factor beta 1 (TGFB1) Successful Target Target Info [3]
RAC-gamma serine/threonine-protein kinase (AKT3) Successful Target Target Info [4]
Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Target Info [3]
Protein(s) Regulated by This miRNA Collagen alpha-1(I) chain Regulated Protein [5]
Collagen alpha-1(III) chain Regulated Protein [5]
Collagen alpha-1(V) chain Regulated Protein [5]
Transcription factor jun-D Regulated Protein [6]
References
REF 1 miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction. J Transl Med. 2016 Apr 11;14:84.
REF 2 Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer. Oncotarget. 2017 Feb 28;8(9):14655-14665.
REF 3 Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-1/Smad3. Cell Biochem Funct. 2016 Jul;34(5):326-33.
REF 4 MiRNA-29b suppresses tumor growth through simultaneously inhibiting angiogenesis and tumorigenesis by targeting Akt3. Cancer Lett. 2017 Jul 1;397:111-119.
REF 5 Cyclic stretch and compression forces alter microRNA-29 expression of human periodontal ligament cells.Gene. 2015 Jul 15;566(1):13-7.
REF 6 JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.Am J Physiol Cell Physiol. 2015 May 15;308(10):C813-24.

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