miRNA General Information
miRNA Mature ID hsa-miR-223-5p
miRNA Stemloop AC MI0000300
miRNA Stemloop ID hsa-mir-223
Sequence cguguauuugacaagcugaguu
TTD Target(s) Regulated by This miRNA Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
Epidermal growth factor (EGF) Successful Target Target Info [2]
F-box and WD-40 domain protein 7 (Fbxw7) Literature-reported Target Target Info [3]
Protein(s) Regulated by This miRNA F-box only protein 8 Regulated Protein [4]
Ras-related protein Rab-12 Regulated Protein [5]
References
REF 1 Down-regulation of microRNA-223 promotes degranulation via the PI3K/Akt pathway by targeting IGF-1R in mast cells. PLoS One. 2015 Apr 13;10(4):e0123575.
REF 2 Radiotherapy-induced miR-223 prevents relapse of breast cancer by targeting the EGF pathway. Oncogene. 2016 Sep 15;35(37):4914-26.
REF 3 miR-223/FBW7 axis regulates doxorubicin sensitivity through epithelial mesenchymal transition in non-small cell lung cancer. Am J Transl Res. 2016 Jun 15;8(6):2512-24.
REF 4 FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma.Cancer Lett. 2017 Mar 1;388:85-95.
REF 5 Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia.Cell Rep. 2015 Oct 20;13(3):504-515.

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