miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-210-3p | ||||
miRNA Stemloop AC | MI0000286 | ||||
miRNA Stemloop ID | hsa-mir-210 | ||||
Sequence | cugugcgugugacagcggcuga | ||||
TTD Target(s) Regulated by This miRNA | Tyrosine-protein kinase BTK (ATK) | Successful Target | Target Info | [1] | |
Succinate-semialdehyde dehydrogenase (ALDH5A1) | Successful Target | Target Info | [2] | ||
Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) | Clinical trial Target | Target Info | [3] | ||
Polo-like kinase 1 (PLK1) | Clinical trial Target | Target Info | [4] | ||
Protein-tyrosine phosphatase 1B (PTP1B) | Clinical trial Target | Target Info | [5] | ||
Serine/threonine-protein kinase pim-1 (PIM1) | Clinical trial Target | Target Info | [6] | ||
Brain-derived neurotrophic factor (BDNF) | Clinical trial Target | Target Info | [5] | ||
Hypoxia-inducible factor 1 alpha (HIF-1A) | Clinical trial Target | Target Info | [7] | ||
Lactate dehydrogenase A (LDHA) | Literature-reported Target | Target Info | [8] | ||
Activin receptor type IB (ACVR1B) | Patented-recorded Target | Target Info | [5] | ||
Transferrin receptor protein 1 (TFRC) | Clinical trial Target | Target Info | [9] | ||
Autophagy-related protein 7 (ATG7) | Literature-reported Target | Target Info | [10] | ||
DNA repair protein complementing XP-A cells (XPA) | Literature-reported Target | Target Info | [11] | ||
ETS domain-containing protein Elk-3 (ELK3) | Literature-reported Target | Target Info | [5] | ||
Insulin-like growth factor-binding protein 3 (IGFBP3) | Clinical trial Target | Target Info | [2] | ||
Stathmin-1 (STMN1) | Literature-reported Target | Target Info | [12] | ||
Protein(s) Regulated by This miRNA | Adenomatous polyposis coli protein | Regulated Protein | [5] | ||
Apoptosis-inducing factor 3 | Regulated Protein | [14] | |||
ATP-binding cassette sub-family B member 9 | Regulated Protein | [5] | |||
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | Regulated Protein | [15] | |||
CASP8-associated protein 2 | Regulated Protein | [16] | |||
Chromobox protein homolog 1 | Regulated Protein | [5] | |||
Chromodomain-helicase-DNA-binding protein 9 | Regulated Protein | [5] | |||
CLIP-associating protein 2 | Regulated Protein | [5] | |||
Collagen alpha-2(IV) chain | Regulated Protein | [2] | |||
Cyclin-dependent kinase 10 | Regulated Protein | [5] | |||
Cytochrome c oxidase subunit NDUFA4 | Regulated Protein | [18] | |||
Cytoplasmic polyadenylation element-binding protein 2 | Regulated Protein | [5] | |||
DNA repair protein RAD52 homolog | Regulated Protein | [11] | |||
DNA replication licensing factor MCM3 | Regulated Protein | [2] | |||
Double-strand break repair protein MRE11 | Regulated Protein | [11] | |||
E3 ubiquitin-protein ligase HECTD1 | Regulated Protein | [5] | |||
E3 ubiquitin-protein ligase KCMF1 | Regulated Protein | [20] | |||
E3 ubiquitin-protein ligase MIB1 | Regulated Protein | [5] | |||
EH domain-containing protein 2 | Regulated Protein | [2] | |||
Ephrin-A3 | Regulated Protein | [21] | |||
Fibroblast growth factor receptor-like 1 | Regulated Protein | [22] | |||
Fibroblast growth factor receptor-like 1 | Regulated Protein | [23] | |||
Forkhead box protein N3 | Regulated Protein | [2] | |||
Forkhead box protein P3 | Regulated Protein | [24] | |||
Glycerol-3-phosphate dehydrogenase 1-like protein | Regulated Protein | [5] | |||
Homeobox protein Hox-A1 | Regulated Protein | [6] | |||
Homeobox protein Hox-A3 | Regulated Protein | [5] | |||
Homeobox protein Hox-A9 | Regulated Protein | [6] | |||
Hypoxia-inducible factor 3-alpha | Regulated Protein | [26] | |||
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial | Regulated Protein | [5] | |||
L-lactate dehydrogenase B chain | Regulated Protein | [8] | |||
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 | Regulated Protein | [5] | |||
Max-binding protein MNT | Regulated Protein | [28] | |||
Mid1-interacting protein 1 | Regulated Protein | [5] | |||
Myogenesis-regulating glycosidase | Regulated Protein | [5] | |||
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Regulated Protein | [5] | |||
Neural cell adhesion molecule 1 | Regulated Protein | [5] | |||
Neuronal pentraxin-1 | Regulated Protein | [29] | |||
Nipped-B-like protein | Regulated Protein | [5] | |||
Nucleoporin SEH1 | Regulated Protein | [5] | |||
Phospholipid-transporting ATPase IG | Regulated Protein | [5] | |||
Polypyrimidine tract-binding protein 3 | Regulated Protein | [30] | |||
Probable dimethyladenosine transferase | Regulated Protein | [12] | |||
Protein DENND6A | Regulated Protein | [5] | |||
Protein prenyltransferase alpha subunit repeat-containing protein 1 | Regulated Protein | [5] | |||
SERTA domain-containing protein 2 | Regulated Protein | [5] | |||
SH3 domain-binding glutamic acid-rich-like protein | Regulated Protein | [2] | |||
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 | Regulated Protein | [5] | |||
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | Regulated Protein | [18] | |||
Thrombospondin type-1 domain-containing protein 7A | Regulated Protein | [32] | |||
Transportin-1 | Regulated Protein | [5] | |||
Tumor protein p53-inducible protein 11 | Regulated Protein | [6] | |||
Twist-related protein 1 | Regulated Protein | [33] | |||
Type I inositol 1,4,5-trisphosphate 5-phosphatase | Regulated Protein | [2] | |||
Tyrosine-protein phosphatase non-receptor type 2 | Regulated Protein | [34] | |||
Ubiquilin-1 | Regulated Protein | [5] | |||
Vacuole membrane protein 1 | Regulated Protein | [35] | |||
References | |||||
REF 1 | Targeting BTK through microRNA in chronic lymphocytic leukemia. Blood. 2016 Dec 29;128(26):3101-3112. | ||||
REF 2 | Seed-Milarity confers to hsa-miR-210 and hsa-miR-147b similar functional activity. PLoS One. 2012;7(9):e44919. | ||||
REF 3 | Hydroxysteroid (17-) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia. Hypertension. 2012 Feb;59(2):265-73. | ||||
REF 4 | Long noncoding RNA lnc-RI is a new regulator of mitosis via targeting miRNA-210-3p to release PLK1 mRNA activity. Sci Rep. 2016 May 10;6:25385. | ||||
REF 5 | An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem. 2009 Dec 11;284(50):35134-43. | ||||
REF 6 | Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell. 2009 Sep 24;35(6):856-67. | ||||
REF 7 | Effects of knockdown of miR-210 in combination with ionizing radiation on human hepatoma xenograft in nude mice. Radiat Oncol. 2013 Apr 25;8:102. | ||||
REF 8 | Estrogen and retinoic acid antagonistically regulate several microRNA genes to control aerobic glycolysis in breast cancer cells. Mol Biosyst. 2012 Oct 30;8(12):3242-53. | ||||
REF 9 | EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 May 2;31(9):2207-21. | ||||
REF 10 | Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis. J Extracell Vesicles. 2015 Nov 11;4:28388. | ||||
REF 11 | MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 2009 Feb 1;69(3):1221-9. | ||||
REF 12 | Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. Nat Commun. 2014 Sep 4;5:4497. | ||||
REF 13 | An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem. 2009 Dec 11;284(50):35134-43. | ||||
REF 14 | Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro.Exp Cell Res. 2012 May 1;318(8):944-54. | ||||
REF 15 | miR-210 suppresses BNIP3 to protect against the apoptosis of neural progenitor cells.Stem Cell Res. 2013 Jul;11(1):657-67. | ||||
REF 16 | Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2.J Biol Chem. 2009 Nov 27;284(48):33161-8. | ||||
REF 17 | Seed-Milarity confers to hsa-miR-210 and hsa-miR-147b similar functional activity. PLoS One. 2012;7(9):e44919. | ||||
REF 18 | MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.Cell Death Dis. 2013 Mar 14;4:e544. | ||||
REF 19 | MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 2009 Feb 1;69(3):1221-9. | ||||
REF 20 | MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1.Hypertension. 2014 Oct;64(4):839-45. | ||||
REF 21 | MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3.J Biol Chem. 2008 Jun 6;283(23):15878-83. | ||||
REF 22 | MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1).J Biol Chem. 2011 Jan 7;286(1):420-8. | ||||
REF 23 | MiR-210 links hypoxia with cell proliferation regulation in human Laryngocarcinoma cancer.J Cell Biochem. 2015 Jun;116(6):1039-49. | ||||
REF 24 | Up-regulation of microRNA-210 induces immune dysfunction via targeting FOXP3 in CD4(+) T cells of psoriasis vulgaris.Clin Immunol. 2014 Jan;150(1):22-30. | ||||
REF 25 | Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell. 2009 Sep 24;35(6):856-67. | ||||
REF 26 | MicroRNA response to hypoxic stress in soft tissue sarcoma cells: microRNA mediated regulation of HIF3.BMC Cancer. 2014 Jun 13;14:429. | ||||
REF 27 | Estrogen and retinoic acid antagonistically regulate several microRNA genes to control aerobic glycolysis in breast cancer cells. Mol Biosyst. 2012 Oct 30;8(12):3242-53. | ||||
REF 28 | MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle. 2009 Sep 1;8(17):2756-68. | ||||
REF 29 | Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.FEBS Lett. 2008 Jul 9;582(16):2397-401. | ||||
REF 30 | ROD1 is a seedless target gene of hypoxia-induced miR-210.PLoS One. 2012;7(9):e44651. | ||||
REF 31 | Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. Nat Commun. 2014 Sep 4;5:4497. | ||||
REF 32 | Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A.Sci Rep. 2016 Jan 22;6:19588. | ||||
REF 33 | microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma.Oncotarget. 2017 Mar 28;8(13):20881-20894. | ||||
REF 34 | Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2.Cell Death Dis. 2013 Apr 11;4:e588. | ||||
REF 35 | Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma.Hepatology. 2011 Dec;54(6):2064-75. |
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