miRNA General Information
miRNA Mature ID hsa-miR-15a-3p
miRNA Stemloop AC MI0000069
miRNA Stemloop ID hsa-mir-15a
Sequence caggccauauugugcugccuca
TTD Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [1]
Mixed lineage kinase 1 (MAP3K9) Clinical trial Target Target Info [2]
Polycomb complex protein BMI-1 (BMI1) Clinical trial Target Target Info [3]
Protein(s) Regulated by This miRNA Twist-related protein 1 Regulated Protein [4]
References
REF 1 MiR-15a/16 regulates the growth of myeloma cells, angiogenesis and antitumor immunity by inhibiting Bcl-2, VEGF-A and IL-17 expression in multiple myeloma. Leuk Res. 2016 Oct;49:73-9.
REF 2 Role of miR-15a in intervertebral disc degeneration through targeting MAP3K9. Biomed Pharmacother. 2017 Mar;87:568-574.
REF 3 miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1. Life Sci. 2016 Nov 1;164:60-70.
REF 4 miR-15a-3p and miR-16-1-3p Negatively Regulate Twist1 to Repress Gastric Cancer Cell Invasion and Metastasis.Int J Biol Sci. 2017 Jan 15;13(1):122-134.

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