miRNA General Information
miRNA Mature ID hsa-miR-149-3p
miRNA Stemloop AC MI0000478
miRNA Stemloop ID hsa-mir-149
Sequence agggagggacgggggcugugc
TTD Target(s) Regulated by This miRNA Fibroblast growth factor receptor 1 (FGFR1) Successful Target Target Info [1]
RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Target Info [2]
E2F transcription factor 1 (E2F1) Clinical trial Target Target Info [2]
Protein(s) Regulated by This miRNA Glypican-1 Regulated Protein [1]
Myb-related protein B Regulated Protein [2]
Proto-oncogene Wnt-1 Regulated Protein [5]
References
REF 1 Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. J Cell Sci. 2014 Mar 15;127(Pt 6):1169-78.
REF 2 miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells. Mol Carcinog. 2010 Aug;49(8):719-27.
REF 3 Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. J Cell Sci. 2014 Mar 15;127(Pt 6):1169-78.
REF 4 miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells. Mol Carcinog. 2010 Aug;49(8):719-27.
REF 5 18-glycyrrhetinic acid suppresses gastric cancer by activation of miR-149-3p-Wnt-1 signaling.Oncotarget. 2016 Nov 1;7(44):71960-71973.

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