miRNA General Information
miRNA Mature ID hsa-miR-134-5p
miRNA Stemloop AC MI0000474
miRNA Stemloop ID hsa-mir-134
Sequence ugugacugguugaccagagggg
TTD Target(s) Regulated by This miRNA Erbb2 tyrosine kinase receptor (HER2) Successful Target Target Info [1]
Multidrug resistance-associated protein 1 (ABCC1) Successful Target Target Info [2]
Opioid receptor mu (MOP) Successful Target Target Info [3]
Vascular endothelial growth factor A (VEGFA) Successful Target Target Info [4]
Integrin beta-1 (ITGB1) Clinical trial Target Target Info [5]
PAK-2 protein kinase (PAK2) Literature-reported Target Target Info [6]
Angiopoietin-related protein 4 (ANGPTL4) Literature-reported Target Target Info [7]
Forkhead box protein M1 (FOXM1) Literature-reported Target Target Info [8]
Protein(s) Regulated by This miRNA Golgi phosphoprotein 3 Regulated Protein [9]
Homeobox protein NANOG Regulated Protein [10]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 Regulated Protein [11]
Palmitoyltransferase ZDHHC9 Regulated Protein [12]
Pumilio homolog 2 Regulated Protein [13]
Ras-related protein Rab-27A Regulated Protein [14]
Signal transducer and activator of transcription 5B Regulated Protein [15]
Vimentin Regulated Protein [16]
References
REF 1 High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth. Mol Oncol. 2014 Feb;8(1):93-104.
REF 2 Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis. Eur J Cancer. 2010 Jun;46(9):1692-702.
REF 3 Regulation of -opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation. Eur J Pain. 2013 Mar;17(3):313-23.
REF 4 The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 2008 Mar 5;3(3):e1719.
REF 5 Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin 1 in hepatocellular carcinoma. PLoS One. 2014 Feb 3;9(2):e87665.
REF 6 Down-regulated expression of miR-134 contributes to paclitaxel resistance in human ovarian cancer cells. FEBS Lett. 2015 Oct 7;589(20 Pt B):3154-64.
REF 7 MicroRNA-134 actives lipoprotein lipase-mediated lipid accumulation and inflammatory response by targeting angiopoietin-like 4 in THP-1 macrophages. Biochem Biophys Res Commun. 2016 Apr 8;472(3):410-7.
REF 8 miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells. FEBS Lett. 2012 Oct 19;586(20):3761-5.
REF 9 MicroRNA-134 suppresses cell proliferation in gastric cancer cells via targeting of GOLPH3.Oncol Rep. 2017 Apr;37(4):2441-2448.
REF 10 MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression.Int J Oncol. 2013 May;42(5):1533-40.
REF 11 MiR-134/487b/655 cluster regulates TGF--induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells.Mol Cancer Ther. 2014 Feb;13(2):444-53.
REF 12 MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9.Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17898-903.
REF 13 MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression.EMBO J. 2014 Oct 1;33(19):2231-46.
REF 14 MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.Gene. 2017 Mar 20;605:99-107.
REF 15 Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma.Cell Death Differ. 2014 May;21(5):720-34.
REF 16 Hybrid-polymerase chain reaction to identify novel target genes of miR-134 in paclitaxel resistant human ovarian carcinoma cells. Oncol Lett. 2015 Jun;9(6):2910-2916.

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