miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-134-5p | ||||
miRNA Stemloop AC | MI0000474 | ||||
miRNA Stemloop ID | hsa-mir-134 | ||||
Sequence | ugugacugguugaccagagggg | ||||
TTD Target(s) Regulated by This miRNA | Erbb2 tyrosine kinase receptor (HER2) | Successful Target | Target Info | [1] | |
Multidrug resistance-associated protein 1 (ABCC1) | Successful Target | Target Info | [2] | ||
Opioid receptor mu (MOP) | Successful Target | Target Info | [3] | ||
Vascular endothelial growth factor A (VEGFA) | Successful Target | Target Info | [4] | ||
Integrin beta-1 (ITGB1) | Clinical trial Target | Target Info | [5] | ||
PAK-2 protein kinase (PAK2) | Literature-reported Target | Target Info | [6] | ||
Angiopoietin-related protein 4 (ANGPTL4) | Literature-reported Target | Target Info | [7] | ||
Forkhead box protein M1 (FOXM1) | Literature-reported Target | Target Info | [8] | ||
Protein(s) Regulated by This miRNA | Golgi phosphoprotein 3 | Regulated Protein | [9] | ||
Homeobox protein NANOG | Regulated Protein | [10] | |||
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 | Regulated Protein | [11] | |||
Palmitoyltransferase ZDHHC9 | Regulated Protein | [12] | |||
Pumilio homolog 2 | Regulated Protein | [13] | |||
Ras-related protein Rab-27A | Regulated Protein | [14] | |||
Signal transducer and activator of transcription 5B | Regulated Protein | [15] | |||
Vimentin | Regulated Protein | [16] | |||
References | |||||
REF 1 | High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth. Mol Oncol. 2014 Feb;8(1):93-104. | ||||
REF 2 | Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis. Eur J Cancer. 2010 Jun;46(9):1692-702. | ||||
REF 3 | Regulation of -opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation. Eur J Pain. 2013 Mar;17(3):313-23. | ||||
REF 4 | The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 2008 Mar 5;3(3):e1719. | ||||
REF 5 | Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin 1 in hepatocellular carcinoma. PLoS One. 2014 Feb 3;9(2):e87665. | ||||
REF 6 | Down-regulated expression of miR-134 contributes to paclitaxel resistance in human ovarian cancer cells. FEBS Lett. 2015 Oct 7;589(20 Pt B):3154-64. | ||||
REF 7 | MicroRNA-134 actives lipoprotein lipase-mediated lipid accumulation and inflammatory response by targeting angiopoietin-like 4 in THP-1 macrophages. Biochem Biophys Res Commun. 2016 Apr 8;472(3):410-7. | ||||
REF 8 | miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells. FEBS Lett. 2012 Oct 19;586(20):3761-5. | ||||
REF 9 | MicroRNA-134 suppresses cell proliferation in gastric cancer cells via targeting of GOLPH3.Oncol Rep. 2017 Apr;37(4):2441-2448. | ||||
REF 10 | MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression.Int J Oncol. 2013 May;42(5):1533-40. | ||||
REF 11 | MiR-134/487b/655 cluster regulates TGF--induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells.Mol Cancer Ther. 2014 Feb;13(2):444-53. | ||||
REF 12 | MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9.Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17898-903. | ||||
REF 13 | MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression.EMBO J. 2014 Oct 1;33(19):2231-46. | ||||
REF 14 | MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.Gene. 2017 Mar 20;605:99-107. | ||||
REF 15 | Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma.Cell Death Differ. 2014 May;21(5):720-34. | ||||
REF 16 | Hybrid-polymerase chain reaction to identify novel target genes of miR-134 in paclitaxel resistant human ovarian carcinoma cells. Oncol Lett. 2015 Jun;9(6):2910-2916. |
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