miRNA General Information
miRNA Mature ID hsa-miR-133a-3p
miRNA Stemloop AC MI0000450 | MI0000451
miRNA Stemloop ID hsa-mir-133a-1 | hsa-mir-133a-2
Sequence uuugguccccuucaaccagcug
TTD Target(s) Regulated by This miRNA Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target Target Info [1]
Voltage-gated potassium channel Kv7.1 (KCNQ1) Successful Target Target Info [2]
Caspase-9 (CASP9) Clinical trial Target Target Info [3]
Fascin (FSCN1) Clinical trial Target Target Info [4]
Transforming protein RhoA (RHOA) Discontinued Target Target Info [5]
Hyperpolarization cyclic nucleotide-gated channel 2 (HCN2) Literature-reported Target Target Info [6]
Protein(s) Regulated by This miRNA Actin-related protein 2/3 complex subunit 5 Regulated Protein [7]
Aftiphilin Regulated Protein [8]
Cell division control protein 42 homolog Regulated Protein [9]
Collagen alpha-1(I) chain Regulated Protein [10]
E3 ubiquitin-protein ligase rififylin Regulated Protein [11]
Ferritin light chain Regulated Protein [12]
Forkhead box protein L2 Regulated Protein [13]
Keratin, type II cytoskeletal 7 Regulated Protein [14]
LIM and SH3 domain protein 1 Regulated Protein [15]
Low density lipoprotein receptor adapter protein 1 Regulated Protein [16]
Moesin Regulated Protein [17]
Nuclear receptor subfamily 2 group C member 2 Regulated Protein [18]
PDZ and LIM domain protein 5 Regulated Protein [19]
Phosphatidylcholine:ceramide cholinephosphotransferase 2 Regulated Protein [20]
Phosphatidylinositol 3-kinase regulatory subunit beta Regulated Protein [21]
PR domain zinc finger protein 16 Regulated Protein [22]
PR domain zinc finger protein 16 Regulated Protein [23]
Regulator of G-protein signaling 3 Regulated Protein [21]
Sorting nexin-30 Regulated Protein [20]
SUMO-activating enzyme subunit 2 Regulated Protein [20]
Transcription factor SOX-4 Regulated Protein [24]
Transgelin-2 Regulated Protein [25]
Zinc finger E-box-binding homeobox 1 Regulated Protein [26]
References
REF 1 MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J Biol Chem. 2007 Apr 27;282(17):12363-7.
REF 2 Transcriptional activation by stimulating protein 1 and post-transcriptional repression by muscle-specific microRNAs of IKs-encoding genes and pote... J Cell Physiol. 2007 Aug;212(2):358-67.
REF 3 The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J Cell Sci. 2007 Sep 1;120(Pt 17):3045-52.
REF 4 miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer. Br J Cancer. 2010 Mar 2;102(5):883-91.
REF 5 MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol. 2008 Nov;28(22):6773-84.
REF 6 Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J Biol Chem. 2008 Jul 18;283(29):20045-52.
REF 7 Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma.Int J Oncol. 2012 Jun;40(6):1770-8.
REF 8 Neurotensin--regulated miR-133 is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis.Gut. 2015 Jul;64(7):1095-104.
REF 9 miR-133 is a key negative regulator of CDC42-PAK pathway in gastric cancer.Cell Signal. 2014 Dec;26(12):2667-73.
REF 10 MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension.J Cell Physiol. 2012 Feb;227(2):850-6.
REF 11 Tumor suppressor functions of miR-133a in colorectal cancer.Mol Cancer Res. 2013 Sep;11(9):1051-60.
REF 12 Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin.Int J Oncol. 2013 Nov;43(5):1481-6.
REF 13 microRNA133a targets Foxl2 and promotes differentiation of C2C12 into myogenic progenitor cells.DNA Cell Biol. 2015 Jan;34(1):29-36.
REF 14 Identification of novel microRNA targets based on microRNA signatures in bladder cancer.Int J Cancer. 2009 Jul 15;125(2):345-52.
REF 15 Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer.Urol Oncol. 2012 Jul-Aug;30(4):434-43.
REF 16 Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.J Mol Cell Cardiol. 2017 Apr;105:38-48.
REF 17 Tumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.Biochem Biophys Res Commun. 2012 Feb 10;418(2):378-83.
REF 18 miRNA-133a attenuates lipid accumulation via TR4-CD36 pathway in macrophages.Biochimie. 2016 Aug;127:79-85.
REF 19 miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway.Eur J Cancer. 2013 Dec;49(18):3924-35.
REF 20 Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells.Stem Cells. 2014 Apr;32(4):959-73.
REF 21 Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol Cell Biochem. 2011 May;351(1-2):157-64.
REF 22 MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16.Cell Metab. 2013 Feb 5;17(2):210-24.
REF 23 miR-133a regulates adipocyte browning in vivo.PLoS Genet. 2013;9(7):e1003626.
REF 24 MiR-133a suppresses the migration and invasion of esophageal cancer cells by targeting the EMT regulator SOX4. Am J Transl Res. 2015 Aug 15;7(8):1390-403.
REF 25 The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer.Br J Cancer. 2011 Mar 1;104(5):808-18.
REF 26 Neurotensin-induced miR-133 expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin.Sci Rep. 2016 Feb 23;6:22195.

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