miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-133a-3p | ||||
miRNA Stemloop AC | MI0000450 | MI0000451 | ||||
miRNA Stemloop ID | hsa-mir-133a-1 | hsa-mir-133a-2 | ||||
Sequence | uuugguccccuucaaccagcug | ||||
TTD Target(s) Regulated by This miRNA | Voltage-gated potassium channel Kv11.1 (KCNH2) | Successful Target | Target Info | [1] | |
Voltage-gated potassium channel Kv7.1 (KCNQ1) | Successful Target | Target Info | [2] | ||
Caspase-9 (CASP9) | Clinical trial Target | Target Info | [3] | ||
Fascin (FSCN1) | Clinical trial Target | Target Info | [4] | ||
Transforming protein RhoA (RHOA) | Discontinued Target | Target Info | [5] | ||
Hyperpolarization cyclic nucleotide-gated channel 2 (HCN2) | Literature-reported Target | Target Info | [6] | ||
Protein(s) Regulated by This miRNA | Actin-related protein 2/3 complex subunit 5 | Regulated Protein | [7] | ||
Aftiphilin | Regulated Protein | [8] | |||
Cell division control protein 42 homolog | Regulated Protein | [9] | |||
Collagen alpha-1(I) chain | Regulated Protein | [10] | |||
E3 ubiquitin-protein ligase rififylin | Regulated Protein | [11] | |||
Ferritin light chain | Regulated Protein | [12] | |||
Forkhead box protein L2 | Regulated Protein | [13] | |||
Keratin, type II cytoskeletal 7 | Regulated Protein | [14] | |||
LIM and SH3 domain protein 1 | Regulated Protein | [15] | |||
Low density lipoprotein receptor adapter protein 1 | Regulated Protein | [16] | |||
Moesin | Regulated Protein | [17] | |||
Nuclear receptor subfamily 2 group C member 2 | Regulated Protein | [18] | |||
PDZ and LIM domain protein 5 | Regulated Protein | [19] | |||
Phosphatidylcholine:ceramide cholinephosphotransferase 2 | Regulated Protein | [20] | |||
Phosphatidylinositol 3-kinase regulatory subunit beta | Regulated Protein | [21] | |||
PR domain zinc finger protein 16 | Regulated Protein | [22] | |||
PR domain zinc finger protein 16 | Regulated Protein | [23] | |||
Regulator of G-protein signaling 3 | Regulated Protein | [21] | |||
Sorting nexin-30 | Regulated Protein | [20] | |||
SUMO-activating enzyme subunit 2 | Regulated Protein | [20] | |||
Transcription factor SOX-4 | Regulated Protein | [24] | |||
Transgelin-2 | Regulated Protein | [25] | |||
Zinc finger E-box-binding homeobox 1 | Regulated Protein | [26] | |||
References | |||||
REF 1 | MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J Biol Chem. 2007 Apr 27;282(17):12363-7. | ||||
REF 2 | Transcriptional activation by stimulating protein 1 and post-transcriptional repression by muscle-specific microRNAs of IKs-encoding genes and pote... J Cell Physiol. 2007 Aug;212(2):358-67. | ||||
REF 3 | The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J Cell Sci. 2007 Sep 1;120(Pt 17):3045-52. | ||||
REF 4 | miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer. Br J Cancer. 2010 Mar 2;102(5):883-91. | ||||
REF 5 | MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol. 2008 Nov;28(22):6773-84. | ||||
REF 6 | Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J Biol Chem. 2008 Jul 18;283(29):20045-52. | ||||
REF 7 | Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma.Int J Oncol. 2012 Jun;40(6):1770-8. | ||||
REF 8 | Neurotensin--regulated miR-133 is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis.Gut. 2015 Jul;64(7):1095-104. | ||||
REF 9 | miR-133 is a key negative regulator of CDC42-PAK pathway in gastric cancer.Cell Signal. 2014 Dec;26(12):2667-73. | ||||
REF 10 | MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension.J Cell Physiol. 2012 Feb;227(2):850-6. | ||||
REF 11 | Tumor suppressor functions of miR-133a in colorectal cancer.Mol Cancer Res. 2013 Sep;11(9):1051-60. | ||||
REF 12 | Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin.Int J Oncol. 2013 Nov;43(5):1481-6. | ||||
REF 13 | microRNA133a targets Foxl2 and promotes differentiation of C2C12 into myogenic progenitor cells.DNA Cell Biol. 2015 Jan;34(1):29-36. | ||||
REF 14 | Identification of novel microRNA targets based on microRNA signatures in bladder cancer.Int J Cancer. 2009 Jul 15;125(2):345-52. | ||||
REF 15 | Functional role of LASP1 in cell viability and its regulation by microRNAs in bladder cancer.Urol Oncol. 2012 Jul-Aug;30(4):434-43. | ||||
REF 16 | Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.J Mol Cell Cardiol. 2017 Apr;105:38-48. | ||||
REF 17 | Tumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.Biochem Biophys Res Commun. 2012 Feb 10;418(2):378-83. | ||||
REF 18 | miRNA-133a attenuates lipid accumulation via TR4-CD36 pathway in macrophages.Biochimie. 2016 Aug;127:79-85. | ||||
REF 19 | miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway.Eur J Cancer. 2013 Dec;49(18):3924-35. | ||||
REF 20 | Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells.Stem Cells. 2014 Apr;32(4):959-73. | ||||
REF 21 | Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol Cell Biochem. 2011 May;351(1-2):157-64. | ||||
REF 22 | MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16.Cell Metab. 2013 Feb 5;17(2):210-24. | ||||
REF 23 | miR-133a regulates adipocyte browning in vivo.PLoS Genet. 2013;9(7):e1003626. | ||||
REF 24 | MiR-133a suppresses the migration and invasion of esophageal cancer cells by targeting the EMT regulator SOX4. Am J Transl Res. 2015 Aug 15;7(8):1390-403. | ||||
REF 25 | The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer.Br J Cancer. 2011 Mar 1;104(5):808-18. | ||||
REF 26 | Neurotensin-induced miR-133 expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin.Sci Rep. 2016 Feb 23;6:22195. |
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