miRNA General Information
miRNA Mature ID hsa-miR-125b-5p
miRNA Stemloop AC MI0000446 | MI0000470
miRNA Stemloop ID hsa-mir-125b-1 | hsa-mir-125b-2
Sequence ucccugagacccuaacuuguga
TTD Target(s) Regulated by This miRNA Erbb2 tyrosine kinase receptor (HER2) Successful Target Target Info [1]
Cyclin-dependent kinase 6 (CDK6) Successful Target Target Info [2]
NT-3 growth factor receptor (TrkC) Successful Target Target Info [3]
Smoothened homolog (SMO) Successful Target Target Info [4]
Erbb3 tyrosine kinase receptor (Erbb-3) Clinical trial Target Target Info [1]
M-phase inducer phosphatase 1 (MPIP1) Literature-reported Target Target Info [5]
Apoptosis regulator BAK (BAK) Literature-reported Target Target Info [6]
Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Adenomatous polyposis coli protein Regulated Protein [8]
Amiloride-sensitive sodium channel subunit alpha Regulated Protein [9]
Ankyrin repeat and BTB/POZ domain-containing protein 1 Regulated Protein [10]
Aryl hydrocarbon receptor repressor Regulated Protein [11]
AT-rich interactive domain-containing protein 3A Regulated Protein [12]
AT-rich interactive domain-containing protein 3B Regulated Protein [13]
B-cell lymphoma 3 protein Regulated Protein [14]
Bcl-2-modifying factor Regulated Protein [15]
Bone morphogenetic protein receptor type-1B Regulated Protein [16]
Bone morphogenetic protein receptor type-1B Regulated Protein [17]
CCAAT/enhancer-binding protein alpha Regulated Protein [18]
Cingulin Regulated Protein [19]
Core-binding factor subunit beta Regulated Protein [20]
Cyclin-dependent kinase 4 inhibitor D Regulated Protein [21]
Cyclin-J Regulated Protein [22]
DNA damage-regulated autophagy modulator protein 2 Regulated Protein [23]
Dual specificity protein phosphatase 6 Regulated Protein [24]
E3 SUMO-protein ligase PIAS3 Regulated Protein [25]
E3 ubiquitin-protein ligase TRIM71 Regulated Protein [26]
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Regulated Protein [27]
Endoribonuclease LACTB2 Regulated Protein [28]
Frizzled-6 Regulated Protein [29]
Glutathione synthetase Regulated Protein [30]
GRB2-associated-binding protein 2 Regulated Protein [31]
Hexokinase-2 Regulated Protein [32]
Intercellular adhesion molecule 2 Regulated Protein [33]
Interferon regulatory factor 4 Regulated Protein [34]
Interferon-inducible double-stranded RNA-dependent protein kinase activator A Regulated Protein [35]
Interleukin-6 receptor subunit alpha Regulated Protein [36]
Interleukin-6 receptor subunit alpha Regulated Protein [37]
Keratin, type II cytoskeletal 7 Regulated Protein [38]
Kinesin light chain 2 Regulated Protein [39]
Krueppel-like factor 13 Regulated Protein [40]
Matrix metalloproteinase-26 Regulated Protein [41]
Max dimerization protein 1 Regulated Protein [42]
Methylcytosine dioxygenase TET2 Regulated Protein [43]
Mothers against decapentaplegic homolog 4 Regulated Protein [44]
Multiple epidermal growth factor-like domains protein 9 Regulated Protein [22]
NAD-dependent protein deacetylase sirtuin-7 Regulated Protein [45]
NF-kappa-B inhibitor-interacting Ras-like protein 2 Regulated Protein [46]
Nuclear receptor corepressor 2 Regulated Protein [47]
Phosphatidylcholine transfer protein Regulated Protein [30]
Phosphatidylinositol-glycan biosynthesis class F protein Regulated Protein [48]
Podocalyxin Regulated Protein [49]
PR domain zinc finger protein 1 Regulated Protein [34]
Protein BTG2 Regulated Protein [50]
Protein lin-28 homolog A Regulated Protein [51]
Protein lin-28 homolog B Regulated Protein [52]
Protein SET Regulated Protein [53]
Secreted frizzled-related protein 5 Regulated Protein [54]
Semaphorin-4C Regulated Protein [55]
StAR-related lipid transfer protein 13 Regulated Protein [56]
TBC1 domain family member 1 Regulated Protein [57]
Tumor protein p53-inducible nuclear protein 1 Regulated Protein [58]
Tumor protein p53-inducible nuclear protein 1 Regulated Protein [59]
Vacuolar protein sorting-associated protein 4B Regulated Protein [60]
Vacuolar protein sorting-associated protein 51 homolog Regulated Protein [61]
Zinc finger protein Aiolos Regulated Protein [30]
Zinc finger protein Eos Regulated Protein [30]
Zinc finger protein Helios Regulated Protein [30]
References
REF 1 Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem. 2007 Jan 12;282(2):1479-86.
REF 2 Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet. 2005 Dec 15;14(24):3813-21.
REF 3 The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7957-62.
REF 4 Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J. 2008 Oct 8;27(19):2616-27.
REF 5 The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007 Aug 15;67(16):7713-22.
REF 6 An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19983-8.
REF 7 p16(INK4a) translation suppressed by miR-24. PLoS One. 2008 Mar 26;3(3):e1864.
REF 8 CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer.Sci Rep. 2017 Feb 8;7:42226.
REF 9 miR-125b inhibits hepatitis B virus expression in vitro through targeting of the SCNN1A gene.Arch Virol. 2014 Dec;159(12):3335-43.
REF 10 MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA.Haematologica. 2012 Nov;97(11):1713-21.
REF 11 miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury.Cell Death Dis. 2013 Oct 31;4:e899.
REF 12 B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells.Leukemia. 2012 Oct;26(10):2224-32.
REF 13 miR-125b targets ARID3B in breast cancer cells.Cell Struct Funct. 2012;37(1):27-38.
REF 14 MiR-125b targets BCL3 and suppresses ovarian cancer proliferation.Int J Cancer. 2011 May 15;128(10):2274-83.
REF 15 MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf.Cell Physiol Biochem. 2009;23(4-6):347-58.
REF 16 A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis.Cancer Res. 2009 Sep 15;69(18):7459-65.
REF 17 MiR-125b Regulates the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting BMPR1b.Cell Physiol Biochem. 2017;41(2):530-542.
REF 18 The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBP.Leukemia. 2015 Dec;29(12):2442-5.
REF 19 miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea.Gut. 2017 Sep;66(9):1537-1538.
REF 20 miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies.J Biol Chem. 2011 Nov 4;286(44):38253-63.
REF 21 miR-125b modulates megakaryocyte maturation by targeting the cell-cycle inhibitor p19INK4D.Cell Death Dis. 2016 Oct 20;7(10):e2430.
REF 22 miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-, CCNJ, and MEGF9.PLoS One. 2013 Oct 3;8(10):e76247.
REF 23 MicroRNA-125b promotes tumor growth and suppresses apoptosis by targeting DRAM2 in retinoblastoma.Eye (Lond). 2016 Dec;30(12):1630-1638.
REF 24 MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.EMBO J. 2014 Aug 1;33(15):1667-80.
REF 25 miR-125b inhibitor may enhance the invasion-prevention activity of temozolomide in glioblastoma stem cells by targeting PIAS3.BioDrugs. 2014 Feb;28(1):41-54.
REF 26 Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation.J Biol Chem. 2005 Apr 29;280(17):16635-41.
REF 27 ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC).PLoS One. 2013 Aug 5;8(8):e72829.
REF 28 MicroRNA-125b-5p attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production by targeting inhibiting LACTB in THP-1 macrophages.Arch Biochem Biophys. 2016 Jan 15;590:64-71.
REF 29 A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.Nat Commun. 2016 Oct 4;7:12885.
REF 30 The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. Blood. 2012 Sep 27;120(13):2631-8.
REF 31 Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b.J Biol Chem. 2015 Oct 30;290(44):26627-37.
REF 32 MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.J Biol Chem. 2012 Jun 29;287(27):23227-35.
REF 33 MicroRNA-125b regulates proliferation and radioresistance of oral squamous cell carcinoma.Br J Cancer. 2013 May 14;108(9):1817-21.
REF 34 MicroRNA 125b inhibition of B cell differentiation in germinal centers.Int Immunol. 2010 Jul;22(7):583-92.
REF 35 Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs.PLoS Genet. 2011 Sep;7(9):e1002242.
REF 36 MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R.Oncogene. 2013 Jun 20;32(25):3071-9.
REF 37 MicroRNA-125b functions as a tumor suppressor in hepatocellular carcinoma cells.Int J Mol Sci. 2012;13(7):8762-74.
REF 38 Identification of novel microRNA targets based on microRNA signatures in bladder cancer.Int J Cancer. 2009 Jul 15;125(2):345-52.
REF 39 High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.Br J Cancer. 2015 Mar 3;112(5):874-82.
REF 40 Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009 Jul;48(7):569-82.
REF 41 MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day.Sci Rep. 2016 May 4;6:25302.
REF 42 miR-125b promotes cell death by targeting spindle assembly checkpoint gene MAD1 and modulating mitotic progression.Cell Death Differ. 2013 Mar;20(3):430-42.
REF 43 An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.Cell Rep. 2013 Oct 31;5(2):471-81.
REF 44 miR-125 potentiates early neural specification of human embryonic stem cells.Development. 2012 Apr;139(7):1247-57.
REF 45 Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.Hepatology. 2013 Mar;57(3):1055-67.
REF 46 Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages.J Immunol. 2010 May 1;184(9):5029-37.
REF 47 miR-125b Regulation of Androgen Receptor Signaling Via Modulation of the Receptor Complex Co-Repressor NCOR2.Biores Open Access. 2012 Apr;1(2):55-62.
REF 48 Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer.J Hepatol. 2011 Dec;55(6):1339-45.
REF 49 MicroRNA-125b is involved in atherosclerosis obliterans in vitro by targeting podocalyxin.Mol Med Rep. 2015 Jul;12(1):561-8.
REF 50 Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation.Biochem Biophys Res Commun. 2016 Sep 30;478(4):1758-63.
REF 51 miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation.Biochem Biophys Res Commun. 2008 Apr 4;368(2):267-72.
REF 52 MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2.Hepatology. 2010 Nov;52(5):1731-40.
REF 53 MicroRNA-125b Suppresses Ovarian Cancer Progression via Suppression of the Epithelial-Mesenchymal Transition Pathway by Targeting the SET Protein.Cell Physiol Biochem. 2016;39(2):501-10.
REF 54 MiR-125b regulates SFRP5 expression to promote growth and activation of cardiac fibroblasts.Cell Biol Int. 2016 Nov;40(11):1224-1234.
REF 55 MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells.Oncotarget. 2015 Feb 20;6(5):3268-79.
REF 56 MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells.PLoS One. 2012;7(5):e35435.
REF 57 MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets.Mol Cell Biol. 2009 Oct;29(19):5290-305.
REF 58 MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo.BMC Cancer. 2011 Oct 5;11:425.
REF 59 MicroRNA-125b promotes tumor metastasis through targeting tumor protein 53-induced nuclear protein 1 in patients with non-small-cell lung cancer.Cancer Cell Int. 2015 Sep 17;15:84.
REF 60 miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survival.Genes Dev. 2014 Nov 15;28(22):2532-46.
REF 61 miRNA-dependent cross-talk between VEGF and Ang-2 in hypoxia-induced microvascular dysfunction. Biochem Biophys Res Commun. 2014 Sep 26;452(3):428-35.

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