miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-125b-5p | ||||
miRNA Stemloop AC | MI0000446 | MI0000470 | ||||
miRNA Stemloop ID | hsa-mir-125b-1 | hsa-mir-125b-2 | ||||
Sequence | ucccugagacccuaacuuguga | ||||
TTD Target(s) Regulated by This miRNA | Erbb2 tyrosine kinase receptor (HER2) | Successful Target | Target Info | [1] | |
Cyclin-dependent kinase 6 (CDK6) | Successful Target | Target Info | [2] | ||
NT-3 growth factor receptor (TrkC) | Successful Target | Target Info | [3] | ||
Smoothened homolog (SMO) | Successful Target | Target Info | [4] | ||
Erbb3 tyrosine kinase receptor (Erbb-3) | Clinical trial Target | Target Info | [1] | ||
M-phase inducer phosphatase 1 (MPIP1) | Literature-reported Target | Target Info | [5] | ||
Apoptosis regulator BAK (BAK) | Literature-reported Target | Target Info | [6] | ||
Multiple tumor suppressor 1 (CDKN2A) | Literature-reported Target | Target Info | [7] | ||
Protein(s) Regulated by This miRNA | Adenomatous polyposis coli protein | Regulated Protein | [8] | ||
Amiloride-sensitive sodium channel subunit alpha | Regulated Protein | [9] | |||
Ankyrin repeat and BTB/POZ domain-containing protein 1 | Regulated Protein | [10] | |||
Aryl hydrocarbon receptor repressor | Regulated Protein | [11] | |||
AT-rich interactive domain-containing protein 3A | Regulated Protein | [12] | |||
AT-rich interactive domain-containing protein 3B | Regulated Protein | [13] | |||
B-cell lymphoma 3 protein | Regulated Protein | [14] | |||
Bcl-2-modifying factor | Regulated Protein | [15] | |||
Bone morphogenetic protein receptor type-1B | Regulated Protein | [16] | |||
Bone morphogenetic protein receptor type-1B | Regulated Protein | [17] | |||
CCAAT/enhancer-binding protein alpha | Regulated Protein | [18] | |||
Cingulin | Regulated Protein | [19] | |||
Core-binding factor subunit beta | Regulated Protein | [20] | |||
Cyclin-dependent kinase 4 inhibitor D | Regulated Protein | [21] | |||
Cyclin-J | Regulated Protein | [22] | |||
DNA damage-regulated autophagy modulator protein 2 | Regulated Protein | [23] | |||
Dual specificity protein phosphatase 6 | Regulated Protein | [24] | |||
E3 SUMO-protein ligase PIAS3 | Regulated Protein | [25] | |||
E3 ubiquitin-protein ligase TRIM71 | Regulated Protein | [26] | |||
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase | Regulated Protein | [27] | |||
Endoribonuclease LACTB2 | Regulated Protein | [28] | |||
Frizzled-6 | Regulated Protein | [29] | |||
Glutathione synthetase | Regulated Protein | [30] | |||
GRB2-associated-binding protein 2 | Regulated Protein | [31] | |||
Hexokinase-2 | Regulated Protein | [32] | |||
Intercellular adhesion molecule 2 | Regulated Protein | [33] | |||
Interferon regulatory factor 4 | Regulated Protein | [34] | |||
Interferon-inducible double-stranded RNA-dependent protein kinase activator A | Regulated Protein | [35] | |||
Interleukin-6 receptor subunit alpha | Regulated Protein | [36] | |||
Interleukin-6 receptor subunit alpha | Regulated Protein | [37] | |||
Keratin, type II cytoskeletal 7 | Regulated Protein | [38] | |||
Kinesin light chain 2 | Regulated Protein | [39] | |||
Krueppel-like factor 13 | Regulated Protein | [40] | |||
Matrix metalloproteinase-26 | Regulated Protein | [41] | |||
Max dimerization protein 1 | Regulated Protein | [42] | |||
Methylcytosine dioxygenase TET2 | Regulated Protein | [43] | |||
Mothers against decapentaplegic homolog 4 | Regulated Protein | [44] | |||
Multiple epidermal growth factor-like domains protein 9 | Regulated Protein | [22] | |||
NAD-dependent protein deacetylase sirtuin-7 | Regulated Protein | [45] | |||
NF-kappa-B inhibitor-interacting Ras-like protein 2 | Regulated Protein | [46] | |||
Nuclear receptor corepressor 2 | Regulated Protein | [47] | |||
Phosphatidylcholine transfer protein | Regulated Protein | [30] | |||
Phosphatidylinositol-glycan biosynthesis class F protein | Regulated Protein | [48] | |||
Podocalyxin | Regulated Protein | [49] | |||
PR domain zinc finger protein 1 | Regulated Protein | [34] | |||
Protein BTG2 | Regulated Protein | [50] | |||
Protein lin-28 homolog A | Regulated Protein | [51] | |||
Protein lin-28 homolog B | Regulated Protein | [52] | |||
Protein SET | Regulated Protein | [53] | |||
Secreted frizzled-related protein 5 | Regulated Protein | [54] | |||
Semaphorin-4C | Regulated Protein | [55] | |||
StAR-related lipid transfer protein 13 | Regulated Protein | [56] | |||
TBC1 domain family member 1 | Regulated Protein | [57] | |||
Tumor protein p53-inducible nuclear protein 1 | Regulated Protein | [58] | |||
Tumor protein p53-inducible nuclear protein 1 | Regulated Protein | [59] | |||
Vacuolar protein sorting-associated protein 4B | Regulated Protein | [60] | |||
Vacuolar protein sorting-associated protein 51 homolog | Regulated Protein | [61] | |||
Zinc finger protein Aiolos | Regulated Protein | [30] | |||
Zinc finger protein Eos | Regulated Protein | [30] | |||
Zinc finger protein Helios | Regulated Protein | [30] | |||
References | |||||
REF 1 | Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem. 2007 Jan 12;282(2):1479-86. | ||||
REF 2 | Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet. 2005 Dec 15;14(24):3813-21. | ||||
REF 3 | The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7957-62. | ||||
REF 4 | Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J. 2008 Oct 8;27(19):2616-27. | ||||
REF 5 | The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007 Aug 15;67(16):7713-22. | ||||
REF 6 | An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19983-8. | ||||
REF 7 | p16(INK4a) translation suppressed by miR-24. PLoS One. 2008 Mar 26;3(3):e1864. | ||||
REF 8 | CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer.Sci Rep. 2017 Feb 8;7:42226. | ||||
REF 9 | miR-125b inhibits hepatitis B virus expression in vitro through targeting of the SCNN1A gene.Arch Virol. 2014 Dec;159(12):3335-43. | ||||
REF 10 | MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA.Haematologica. 2012 Nov;97(11):1713-21. | ||||
REF 11 | miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury.Cell Death Dis. 2013 Oct 31;4:e899. | ||||
REF 12 | B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells.Leukemia. 2012 Oct;26(10):2224-32. | ||||
REF 13 | miR-125b targets ARID3B in breast cancer cells.Cell Struct Funct. 2012;37(1):27-38. | ||||
REF 14 | MiR-125b targets BCL3 and suppresses ovarian cancer proliferation.Int J Cancer. 2011 May 15;128(10):2274-83. | ||||
REF 15 | MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf.Cell Physiol Biochem. 2009;23(4-6):347-58. | ||||
REF 16 | A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis.Cancer Res. 2009 Sep 15;69(18):7459-65. | ||||
REF 17 | MiR-125b Regulates the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting BMPR1b.Cell Physiol Biochem. 2017;41(2):530-542. | ||||
REF 18 | The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBP.Leukemia. 2015 Dec;29(12):2442-5. | ||||
REF 19 | miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea.Gut. 2017 Sep;66(9):1537-1538. | ||||
REF 20 | miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies.J Biol Chem. 2011 Nov 4;286(44):38253-63. | ||||
REF 21 | miR-125b modulates megakaryocyte maturation by targeting the cell-cycle inhibitor p19INK4D.Cell Death Dis. 2016 Oct 20;7(10):e2430. | ||||
REF 22 | miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-, CCNJ, and MEGF9.PLoS One. 2013 Oct 3;8(10):e76247. | ||||
REF 23 | MicroRNA-125b promotes tumor growth and suppresses apoptosis by targeting DRAM2 in retinoblastoma.Eye (Lond). 2016 Dec;30(12):1630-1638. | ||||
REF 24 | MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.EMBO J. 2014 Aug 1;33(15):1667-80. | ||||
REF 25 | miR-125b inhibitor may enhance the invasion-prevention activity of temozolomide in glioblastoma stem cells by targeting PIAS3.BioDrugs. 2014 Feb;28(1):41-54. | ||||
REF 26 | Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation.J Biol Chem. 2005 Apr 29;280(17):16635-41. | ||||
REF 27 | ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC).PLoS One. 2013 Aug 5;8(8):e72829. | ||||
REF 28 | MicroRNA-125b-5p attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production by targeting inhibiting LACTB in THP-1 macrophages.Arch Biochem Biophys. 2016 Jan 15;590:64-71. | ||||
REF 29 | A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.Nat Commun. 2016 Oct 4;7:12885. | ||||
REF 30 | The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. Blood. 2012 Sep 27;120(13):2631-8. | ||||
REF 31 | Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b.J Biol Chem. 2015 Oct 30;290(44):26627-37. | ||||
REF 32 | MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene.J Biol Chem. 2012 Jun 29;287(27):23227-35. | ||||
REF 33 | MicroRNA-125b regulates proliferation and radioresistance of oral squamous cell carcinoma.Br J Cancer. 2013 May 14;108(9):1817-21. | ||||
REF 34 | MicroRNA 125b inhibition of B cell differentiation in germinal centers.Int Immunol. 2010 Jul;22(7):583-92. | ||||
REF 35 | Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs.PLoS Genet. 2011 Sep;7(9):e1002242. | ||||
REF 36 | MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R.Oncogene. 2013 Jun 20;32(25):3071-9. | ||||
REF 37 | MicroRNA-125b functions as a tumor suppressor in hepatocellular carcinoma cells.Int J Mol Sci. 2012;13(7):8762-74. | ||||
REF 38 | Identification of novel microRNA targets based on microRNA signatures in bladder cancer.Int J Cancer. 2009 Jul 15;125(2):345-52. | ||||
REF 39 | High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.Br J Cancer. 2015 Mar 3;112(5):874-82. | ||||
REF 40 | Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009 Jul;48(7):569-82. | ||||
REF 41 | MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day.Sci Rep. 2016 May 4;6:25302. | ||||
REF 42 | miR-125b promotes cell death by targeting spindle assembly checkpoint gene MAD1 and modulating mitotic progression.Cell Death Differ. 2013 Mar;20(3):430-42. | ||||
REF 43 | An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.Cell Rep. 2013 Oct 31;5(2):471-81. | ||||
REF 44 | miR-125 potentiates early neural specification of human embryonic stem cells.Development. 2012 Apr;139(7):1247-57. | ||||
REF 45 | Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.Hepatology. 2013 Mar;57(3):1055-67. | ||||
REF 46 | Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages.J Immunol. 2010 May 1;184(9):5029-37. | ||||
REF 47 | miR-125b Regulation of Androgen Receptor Signaling Via Modulation of the Receptor Complex Co-Repressor NCOR2.Biores Open Access. 2012 Apr;1(2):55-62. | ||||
REF 48 | Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer.J Hepatol. 2011 Dec;55(6):1339-45. | ||||
REF 49 | MicroRNA-125b is involved in atherosclerosis obliterans in vitro by targeting podocalyxin.Mol Med Rep. 2015 Jul;12(1):561-8. | ||||
REF 50 | Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation.Biochem Biophys Res Commun. 2016 Sep 30;478(4):1758-63. | ||||
REF 51 | miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation.Biochem Biophys Res Commun. 2008 Apr 4;368(2):267-72. | ||||
REF 52 | MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2.Hepatology. 2010 Nov;52(5):1731-40. | ||||
REF 53 | MicroRNA-125b Suppresses Ovarian Cancer Progression via Suppression of the Epithelial-Mesenchymal Transition Pathway by Targeting the SET Protein.Cell Physiol Biochem. 2016;39(2):501-10. | ||||
REF 54 | MiR-125b regulates SFRP5 expression to promote growth and activation of cardiac fibroblasts.Cell Biol Int. 2016 Nov;40(11):1224-1234. | ||||
REF 55 | MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells.Oncotarget. 2015 Feb 20;6(5):3268-79. | ||||
REF 56 | MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells.PLoS One. 2012;7(5):e35435. | ||||
REF 57 | MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets.Mol Cell Biol. 2009 Oct;29(19):5290-305. | ||||
REF 58 | MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo.BMC Cancer. 2011 Oct 5;11:425. | ||||
REF 59 | MicroRNA-125b promotes tumor metastasis through targeting tumor protein 53-induced nuclear protein 1 in patients with non-small-cell lung cancer.Cancer Cell Int. 2015 Sep 17;15:84. | ||||
REF 60 | miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survival.Genes Dev. 2014 Nov 15;28(22):2532-46. | ||||
REF 61 | miRNA-dependent cross-talk between VEGF and Ang-2 in hypoxia-induced microvascular dysfunction. Biochem Biophys Res Commun. 2014 Sep 26;452(3):428-35. |
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