Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DVQ37G
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| Drug Name |
(S)-4-(Ethylsulfonyl)benzoylalanine
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| Synonyms |
S-ESBA
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| Drug Type |
Small molecular drug
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| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7; ICD-9: 331.83] | Preclinical | [1] | |
| Schizophrenia [ICD-11: 6A20] | Preclinical | [1] | ||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kynurenine oxoglutarate transaminase II (AADAT) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. | |||
| REF 2 | Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 2009 Mar 3;159(1):196-203. | |||
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