Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D4XBR9
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| Drug Name |
Pozelimab
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| Synonyms |
REGN3918
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|
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| Drug Type |
Antibody
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| Indication | Large B Cell Lymphoma [ICD-11: 2A81] | Approved | [1] | |
| Protein-losing enteropathy [ICD-11: DA96] | Approved | [1] | ||
| Paroxysmal nocturnal haemoglobinuria [ICD-11: 3A21.0; ICD-10: D59.5] | Phase 2 | [2] | ||
| Company |
Regeneron Pharmaceuticals
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Complement C5 (CO5) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Prion diseases | ||||
| Pertussis | ||||
| Staphylococcus aureus infection | ||||
| Herpes simplex infection | ||||
| Systemic lupus erythematosus | ||||
| Reactome | Activation of C3 and C5 | |||
| Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | ||||
| Regulation of Complement cascade | ||||
| WikiPathways | Complement Activation, Classical Pathway | |||
| Human Complement System | ||||
| Spinal Cord Injury | ||||
| Allograft Rejection | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Complement cascade | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761339 | |||
| REF 2 | ClinicalTrials.gov (NCT04888507) Pozelimab and Cemdisiran Combination Therapy in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Switch From Eculizumab Therapy. U.S. National Institutes of Health. | |||
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