Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z5TQ
|
|||
| Former ID |
DNC004633
|
|||
| Drug Name |
GW-5074
|
|||
| Synonyms |
gw5074; 220904-83-6; GW 5074; Raf1 Kinase Inhibitor I; UNII-B7W8RS1GG2; B7W8RS1GG2; CHEMBL72365; 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone; 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one; (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one; (Z)-3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one; SR-01000075897; STO521; 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one; Tocris-1381
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C15H8Br2INO2
|
|||
| Canonical SMILES |
C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2
|
|||
| InChI |
1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
|
|||
| InChIKey |
LMXYVLFTZRPNRV-KMKOMSMNSA-N
|
|||
| CAS Number |
CAS 1233748-60-1
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
11111232, 11114054, 11114609, 11841304, 14720330, 14762864, 17405073, 24278455, 26752177, 26752178, 26759432, 26759433, 40481489, 47216598, 47662094, 47810572, 48034920, 48259038, 48334292, 48334293, 50104831, 50104832, 50104833, 53777616, 53788372, 57365289, 75630142, 85231065, 90341295, 92303934, 92310164, 99301076, 99302596, 100053923, 103271470, 103984884, 104051640, 114290291, 121361245, 124658755, 124880221, 124880222, 124880223, 124880224, 124880225, 134341838, 134964475, 135325386, 142451115, 152258250
|
|||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8072). | |||
| REF 2 | Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.