Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0YM2S
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| Drug Name |
PMID28270010-Compound-Figure16-b-2
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| Drug Type |
Small molecular drug
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| Company |
ARRAY BIOPHARMA INC
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H25F3N6O2
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| Canonical SMILES |
CC1=C(N(N=C1C2=CN(N=C2)C)C3=CC=CC=C3)NC(=O)NCC4=C(C=CC(=C4)COC)C(F)(F)F
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| InChI |
1S/C25H25F3N6O2/c1-16-22(19-13-30-33(2)14-19)32-34(20-7-5-4-6-8-20)23(16)31-24(35)29-12-18-11-17(15-36-3)9-10-21(18)25(26,27)28/h4-11,13-14H,12,15H2,1-3H3,(H2,29,31,35)
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| InChIKey |
SBSBZPNKXQZAIG-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tropomyosin-related kinase A (TrkA) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Tropomyosin-related kinase A (TrkA) | Target's Patent Info | [1] | |
| KEGG Pathway | MAPK signaling pathway | |||
| Endocytosis | ||||
| Apoptosis | ||||
| Neurotrophin signaling pathway | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Pathways in cancer | ||||
| Transcriptional misregulation in cancer | ||||
| Thyroid cancer | ||||
| Central carbon metabolism in cancer | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Neurotrophic factor-mediated Trk receptor signaling | |||
| Reactome | Frs2-mediated activation | |||
| ARMS-mediated activation | ||||
| NGF-independant TRKA activation | ||||
| PI3K/AKT activation | ||||
| WikiPathways | MAPK Signaling Pathway | |||
| BDNF signaling pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. | |||
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