Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X6LZ
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| Former ID |
DIB018590
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| Drug Name |
3-chlorotyrosine
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| Synonyms |
Monochlorotyrosine; Tyrosine, 3-chloro-; 3-Chloro-DL-tyrosine; C9H10ClNO3; 2-amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; 7298-90-0; AC1L3OFH; AC1Q3M6L; SCHEMBL157442; L-(8CI)-3-chloro-Tyrosine; GTPL5114; CTK7I4440; ACWBBAGYTKWBCD-UHFFFAOYSA-N; AKOS009158821; VZ26714; MCULE-5698335509; KB-31251; LS-177012; A838069; 2-azanyl-3-(3-chloranyl-4-oxidanyl-phenyl)propanoic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H10ClNO3
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| Canonical SMILES |
C1=CC(=C(C=C1CC(C(=O)O)N)Cl)O
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| InChI |
1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
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| InChIKey |
ACWBBAGYTKWBCD-ZETCQYMHSA-N
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| CAS Number |
CAS 7423-93-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:53678
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tyrosine 3-monooxygenase (TH) | Target Info | Inhibitor | [2] |
| BioCyc | Catecholamine biosynthesis | |||
| KEGG Pathway | Tyrosine metabolism | |||
| Metabolic pathways | ||||
| Dopaminergic synapse | ||||
| Prolactin signaling pathway | ||||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Nicotine pharmacodynamics pathway | ||||
| Pathwhiz Pathway | Catecholamine Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| AP-1 transcription factor network | ||||
| p38 signaling mediated by MAPKAP kinases | ||||
| Alpha-synuclein signaling | ||||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| Biogenic Amine Synthesis | ||||
| Dopaminergic Neurogenesis | ||||
| Metabolism of amino acids and derivatives | ||||
| Dopamine metabolism | ||||
| Parkinsons Disease Pathway | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5114). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243). | |||
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