Drug Information
Drug General Information | Top | |||
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Drug ID |
D0X4RS
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Drug Name |
Cortisone Acetate
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Synonyms |
Cortone
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Approved | [1] | |
Therapeutic Class |
Anticancer Agents
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Company |
Pharmacia And Upjohn Co
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Structure |
Download2D MOL |
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Formula |
C23H30O6
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Canonical SMILES |
CC(=O)OCC(=O)C1(CCC2C1(CC(=O)C3C2CCC4=CC(=O)CCC34C)C)O
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InChI |
1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
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InChIKey |
ITRJWOMZKQRYTA-RFZYENFJSA-N
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CAS Number |
CAS 50-04-4
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:3897
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ADReCS Drug ID | BADD_D00533 |
Interaction between the Drug and Microbe | Top | |||
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The Metabolism of Drug Affected by Studied Microbe(s) | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
Studied Microbe: Gut microbiota unspecific | [2] | |||
Metabolic Reaction | Ester hydrolysis and reduction | |||
Experimental Method | High-throughput screening | |||
Description | Cortisone acetate can be metabolized by gut microbiota through ester hydrolysis and reduction. |
Target and Pathway | Top | |||
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Target(s) | Steroid hormone receptor ERR (ESRR) | Target Info | Modulator | [3] |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. |
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