Drug Information
Drug General Information | Top | |||
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Drug ID |
D0VW6H
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Former ID |
DNC006292
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Drug Name |
6-amino-5-chlorouracil hydrochloride
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Synonyms |
CHEMBL541900
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C4H5Cl2N3O2
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Canonical SMILES |
C1(=C(NC(=O)NC1=O)N)Cl.Cl
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InChI |
1S/C4H4ClN3O2.ClH/c5-1-2(6)7-4(10)8-3(1)9;/h(H4,6,7,8,9,10);1H
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InChIKey |
LZWPDUHEHWOBPF-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
KEGG Pathway | Pyrimidine metabolism | |||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Bladder cancer | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Pathwhiz Pathway | Pyrimidine Metabolism | |||
WikiPathways | Bladder Cancer | |||
Metabolism of nucleotides | ||||
Fluoropyrimidine Activity |
References | Top | |||
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REF 1 | Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. |
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