Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0VD1R
|
|||
| Drug Name |
Suramin
|
|||
| Synonyms |
Antrypol; Belganyl; Farma; Fourneau; Germanin; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride; SVR; Suramine; SURAMIN SODIUM; Sodium suramin; Suramine sodium; Farma 939; Naganol 6 Na; Germanin (TN); SGCTO-001
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | African trypanosomiasis [ICD-11: 1F51; ICD-10: B56, B56.9; ICD-9: 86.5] | Phase 1 | [1] | |
| Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Investigative | [2] | ||
| Therapeutic Class |
Antiviral Agents
|
|||
| Company |
Bayer Pharmaceuticals Corporation
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C51H40N6O23S6
|
|||
| Canonical SMILES |
CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C
|
|||
| InChI |
1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
|
|||
| InChIKey |
FIAFUQMPZJWCLV-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 145-63-1
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
10175, 544513, 595952, 841306, 5325056, 7890636, 8024358, 8024470, 8153296, 11341933, 11362116, 11364809, 11367371, 11369933, 11371568, 11374912, 11378100, 11487518, 11490540, 11493061, 11495691, 14709929, 14792752, 24770262, 24875087, 26697081, 26756673, 29224413, 46488321, 46491094, 46507013, 47291251, 47440394, 49996875, 53789045, 57280266, 57322738, 80234645, 85209323, 103190607, 103975506, 104309017, 124634028, 124892421, 124892422, 125086901, 126687992, 127316601, 127316602, 127316603
|
|||
| ChEBI ID |
CHEBI:45906
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | COVID-19 RNA-directed RNA polymerase (RdRp) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Arsenicals (Melarsoprol), Pentamidine and Suramin in the Treatment of Human African Trypanosomiasis. Parasitol Res. 2003 May;90(1):71-9. | |||
| REF 2 | Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.