Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0V8EH
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| Former ID |
DNC000821
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| Drug Name |
Isoxazol
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| Synonyms |
Isoxazol; C23H33NO2; Azastenum [INN-Latin]; Azasteno [INN-Spanish]; WIN 17625; AC1L19IF; 4,4,17-Trimethylandrosta-2,5-dieno(2,3-d)isoxazol-17beta-ol; 4,4,17-alpha-Trimethylandrost-5-eno(2,3-d)isoxazol-17-ol; 17beta-Hydroxy-4,4,17alpha-trimethylandrost-5-en-(2,3d)-isoxazole; (17beta)-4,4,17-Trimethylandrosta-2,5-diene(3,2-d)isoxazol-17-ol; Androsta-2,5-dieno(2,3-d)isoxazol-17-ol, 4,4,17-trimethyl-, (17beta)-; Win 17,625; LS-19331; ANDROSTA-2,5-DIENO(2,3-d)ISOXAZOL-17-beta-OL, 4,4,17-TRIMETHYL-; (17 beta)-4,4,17-trimethyla
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H33NO2
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| Canonical SMILES |
CC1(C2=CCC3C4CCC(C4(CCC3C2(CC5=C1ON=C5)C)C)(C)O)C
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| InChI |
1S/C23H33NO2/c1-20(2)18-7-6-15-16(21(18,3)12-14-13-24-26-19(14)20)8-10-22(4)17(15)9-11-23(22,5)25/h7,13,15-17,25H,6,8-12H2,1-5H3/t15?,16-,17-,21?,22?,23-/m0/s1
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| InChIKey |
AXLOCHLTNQDFFS-BELXDXCXSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. | |||
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