Drug Information
Drug General Information | Top | |||
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Drug ID |
D0UD6X
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Drug Name |
Imidazopyridazine derivative 3
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Synonyms |
PMID26936077-Compound-41
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Drug Type |
Small molecular drug
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Indication | Inflammation [ICD-11: 1A00-CA43.1] | Patented | [1] | |
Pain [ICD-11: MG30-MG3Z] | Patented | [1] | ||
Structure |
Download2D MOL |
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Formula |
C22H20ClF3N4O3
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Canonical SMILES |
CCOC(=O)C1CCN(CC1)C(=O)C2=NN3C(=CC(=NC3=C2)C4=CC=C(C=C4)Cl)C(F)(F)F
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InChI |
1S/C22H20ClF3N4O3/c1-2-33-21(32)14-7-9-29(10-8-14)20(31)17-12-19-27-16(13-3-5-15(23)6-4-13)11-18(22(24,25)26)30(19)28-17/h3-6,11-12,14H,2,7-10H2,1H3
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InChIKey |
GQAPMAOCKZPCGZ-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Proteinase activated receptor 2 (PAR2) | Target Info | Antagonist | [1] |
Target's Patent Info | Proteinase activated receptor 2 (PAR2) | Target's Patent Info | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Inflammatory mediator regulation of TRP channels | ||||
African trypanosomiasis | ||||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. |
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