Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0U9QD
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| Former ID |
DIB018676
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| Drug Name |
6-fluorotryptophan
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| Synonyms |
6-Fluoro-DL-tryptophan; 7730-20-3; 6-fluorotryptophan; 2-amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid; DL-Tryptophan, 6-fluoro-; DL-6-Fluorotryptophane; (+-)-6-Fluorotryptophan; Tryptophan, 6-fluoro-, DL-; NSC 9364; 6-fluoro-D,L-tryptophan; EINECS 231-788-6; BRN 0482552; Tryptophan, 6-fluoro-; ST072163; 2-amino-3-(6-fluoroindol-3-yl)propanoic acid; 6-Fluoro-DL-tryptophan, 97%; D-Tryptophan, 6-fluoro-; 343-92-0; 6-Fluorotryptophan, DL-; ACMC-20mbi4; AC1Q5S5W; SCHEMBL248870; GTPL5126; CHEMBL472222; AC1L3T80; SCHEMBL18029199
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C11H11FN2O2
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| Canonical SMILES |
C1=CC2=C(C=C1F)NC=C2CC(C(=O)O)N
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| InChI |
1S/C11H11FN2O2/c12-7-1-2-8-6(3-9(13)11(15)16)5-14-10(8)4-7/h1-2,4-5,9,14H,3,13H2,(H,15,16)
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| InChIKey |
YMEXGEAJNZRQEH-UHFFFAOYSA-N
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| CAS Number |
CAS 7730-20-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
74861, 3134937, 5199198, 10226852, 15341314, 24894946, 44425478, 48496152, 49747511, 50059061, 53792613, 57335951, 77219520, 85086155, 87619219, 103617497, 103805920, 104414045, 117543473, 117650867, 124573739, 125374298, 125813741, 126693443, 129815767, 135051483, 135076321, 135377016, 137088228, 142422778, 143465140, 152055851, 162087408, 162205300, 162362853, 163132047, 163788981, 164805270, 169350930, 174537006, 178101819, 179325543, 184021893, 184588075, 186003757, 187567765, 202565312, 206251036, 224520457, 226598318
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | L-Tryptophan hydroxylase 2 (TPH2) | Target Info | Inhibitor | [2] |
| Tryptophan 5-hydroxylase 1 (TPH1) | Target Info | Inhibitor | [2] | |
| BioCyc | Superpathway of tryptophan utilization | |||
| Serotonin and melatonin biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Panther Pathway | 5-Hydroxytryptamine biosynthesis | |||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Biogenic Amine Synthesis | ||||
| Tryptophan metabolism | ||||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5126). | |||
| REF 2 | (+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9. | |||
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