Drug Information
Drug General Information | Top | |||
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Drug ID |
D0U7VC
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Drug Name |
1,2-diamino cyclopentane-based derivative 7
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Synonyms |
PMID26593218-Compound-29
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Drug Type |
Small molecular drug
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Company |
TAKEDA CAMBRIDGE LIMITED TAKEDA PHARMACEUTICAL COMPANY LIMITED
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Structure |
Download2D MOL |
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Formula |
C22H24FN3O3S
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Canonical SMILES |
CN(C1CCCC1NC2=NC3=C(S2)C=C(C=C3)F)C(=O)C4=C(C=CC=C4OC)OC
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InChI |
1S/C22H24FN3O3S/c1-26(21(27)20-17(28-2)8-5-9-18(20)29-3)16-7-4-6-14(16)24-22-25-15-11-10-13(23)12-19(15)30-22/h5,8-12,14,16H,4,6-7H2,1-3H3,(H,24,25)/t14-,16-/m0/s1
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InChIKey |
QIQQOZYTKFYTFE-HOCLYGCPSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Orexin receptor type 1 (HCRTR1) | Target Info | Antagonist | [1] |
Orexin receptor type 2 (HCRTR2) | Target Info | Antagonist | [1] | |
Target's Patent Info | Orexin receptor type 1 (HCRTR1) | Target's Patent Info | [1] | |
Orexin receptor type 2 (HCRTR2) | Target's Patent Info | [1] | ||
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | G alpha (q) signalling events | |||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. |
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