Target and Its Patented Drug(s)

Content Navigation (  All   None )                                      
Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T69485 Target Info
Target Name Orexin receptor type 2 (HCRTR2)
Synonyms Ox2r; Ox2-R; Ox-2-R; Orexin-2 receptor; Hypocretin receptor type 2; HFGANP
Target Type Successful Target
Gene Name HCRTR2
Biochemical Class GPCR rhodopsin
UniProt ID
OX2R_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2015124934
Title Substituted Cyclopentanes, Tetrahydrofuranes and Pyrrolidines As orexin Receptor Antagonists.
Abstract The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, Formula (I) wherein L,X, Ra, Rb, R 1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
Applicant(s) Takeda Cambridge Limited Takeda Pharmaceutical Company Limited
Representative Drug(s) D0CG0D Drug Info IC50 > 10000 nM Click to Show More [1]
2 D0EG3N Drug Info IC50 > 10000 nM [1]
Patent ID WO2015124932
Title 1,2-Substituted Cyclopentanes As orexin Receptor Antagonists.
Abstract The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, (I) wherein L,X, Ra, Rb, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
Applicant(s) Takeda Cambridge Limited Takeda Pharmaceutical Company Limited
Representative Drug(s) D09XLY Drug Info IC50 = 5569 nM Click to Show More [1]
2 D06OTA Drug Info IC50 > 10000 nM [1]
3 D0S4UG Drug Info IC50 > 10000 nM [1]
4 D0U9WX Drug Info IC50 > 10000 nM [1]
References  Top
REF 1 Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.