Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S7BK
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| Former ID |
DNC001065
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| Drug Name |
Orotic acid
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| Synonyms |
65-86-1; 6-Carboxyuracil; Oropur; Orodin; Orotonin; Orotonsan; Oroturic; Orotyl; Whey factor; Vitamin B13; 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid; Uracil-6-carboxylic acid; 6-Uracilcarboxylic acid; Animal galactose factor; Orotsaeure; Molkensaeure; Uracil-6-carbosaeure; 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-; 2,6-Dihydroxypyrimidine-4-carboxylic acid; 2,6-Dihydroxy-4-pyrimidinecarboxylic acid; Orotsaeure [German]; Acidum oroticum; Acide orotique; Acido orotico; Acidum oroti
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C5H4N2O4
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| Canonical SMILES |
C1=C(NC(=O)NC1=O)C(=O)O
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| InChI |
1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
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| InChIKey |
PXQPEWDEAKTCGB-UHFFFAOYSA-N
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| CAS Number |
CAS 65-86-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3589, 75164, 595884, 605292, 798786, 823683, 823686, 823696, 823698, 828981, 833549, 833554, 834609, 836839, 836843, 838458, 838851, 841447, 3134136, 3154676, 4583105, 5466129, 7847123, 7889608, 8013736, 8020780, 8027091, 8137966, 8144922, 8150894, 10531957, 10589301, 15120234, 16877294, 16956134, 17388814, 22394337, 22394342, 22394347, 22394367, 24439324, 24897967, 26709670, 46504149, 46504235, 46508903, 48423871, 48425464, 48426230, 49737846
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| ChEBI ID |
CHEBI:16742
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4690). | |||
| REF 2 | Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. Biochem Pharmacol. 1988 Oct 15;37(20):3807-16. | |||
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