Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S6VX
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| Former ID |
DIB007375
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| Drug Name |
CGP-40215A
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| Synonyms |
Cgp-40215A; Cgp 40215A; Bis((3-(aminoiminomethyl)phenyl)methylene)carbonimidic dihydrazide trihydrochloride; Carbonimidic dihydrazide, bis((3-(aminoiminomethyl)phenyl)methylene)-, trihydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Pneumocystis pneumonia [ICD-11: CA40.20; ICD-10: B59] | Terminated | [1] | |
| Company |
Novartis AG
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| Structure |
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Download2D MOL |
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| Formula |
C17H22Cl3N9
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| Canonical SMILES |
C1=CC(=CC(=C1)C(=N)N)C=NNC(=NN=CC2=CC(=CC=C2)C(=N)N)N.Cl.Cl.Cl
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| InChI |
1S/C17H19N9.3ClH/c18-15(19)13-5-1-3-11(7-13)9-23-25-17(22)26-24-10-12-4-2-6-14(8-12)16(20)21;;;/h1-10H,(H3,18,19)(H3,20,21)(H3,22,25,26);3*1H/b23-9+,24-10+;;;
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| InChIKey |
OTMBXWAKBWGKPN-VOTJPXFPSA-N
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| CAS Number |
CAS 126534-93-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | S-adenosylmethionine decarboxylase proenzyme (AMD1) | Target Info | Modulator | [1], [2] |
| BioCyc | Methionine salvage cycle III | |||
| Spermine biosynthesis | ||||
| Spermidine biosynthesis | ||||
| KEGG Pathway | Cysteine and methionine metabolism | |||
| Arginine and proline metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Methionine Metabolism | ||||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70. | |||
| REF 2 | S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77. | |||
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