Drug Information
Drug General Information | Top | |||
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Drug ID |
D0S3WR
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Former ID |
DNC010218
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Drug Name |
N,N-dimethyl-4,4-diphenylbutan-1-amine
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Synonyms |
N,N-dimethyl-4,4-diphenylbutan-1-amine; AC1L3QT1; diphenylalkylamine (DPA), 6c; CHEMBL608689; BDBM35937; ZINC5957503; AKOS016035539
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
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Download2D MOL |
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Formula |
C18H23N
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Canonical SMILES |
CN(C)CCCC(C1=CC=CC=C1)C2=CC=CC=C2
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InChI |
1S/C18H23N/c1-19(2)15-9-14-18(16-10-5-3-6-11-16)17-12-7-4-8-13-17/h3-8,10-13,18H,9,14-15H2,1-2H3
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InChIKey |
BDSUMBDGCUOHGR-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
Histamine H1 receptor (H1R) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Inflammatory mediator regulation of TRP channels | ||||
Gap junction | ||||
Serotonergic synapse | ||||
Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
5HT2 type receptor mediated signaling pathway | ||||
Reactome | Histamine receptors | |||
G alpha (q) signalling events | ||||
Serotonin receptors | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
IL-4 Signaling Pathway | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Serotonin Receptor 2 and STAT3 Signaling | ||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
SIDS Susceptibility Pathways | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. |
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