Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S3WH
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| Former ID |
DAP001454
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| Drug Name |
Artemisinin
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| Synonyms |
Arteannuin; Artemisine; Artemisinina; Artemisinine; Artemisininum; Artesin; Huanghuahaosu; Qinghaosu; Qinghosu; Quinghaosu; Artemisinin [INN]; Artemisinina [Spanish]; Artemisinine [French]; Artemisininum [Latin]; Qing Hau SU; Qing Hau Sau; Qing Hau Sau [Chinese]; Qinghaosu [Chinese]; Quing Hau Sau; Artemisinin (INN); Coartem, Artemisinin; Artemisia annua L., extract; GNF-PF-5671; GNF-Pf-5341; Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one; (+)-Arteannuin; (+)-Artemisinin; (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one; (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one; (5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one; 1,5,9-trimethyl-(1R,4S,5R,9R,12S,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one; 3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H22O5
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| Canonical SMILES |
CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C
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| InChI |
1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
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| InChIKey |
BLUAFEHZUWYNDE-NNWCWBAJSA-N
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| CAS Number |
CAS 63968-64-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11729, 597201, 3154164, 8149879, 10321764, 11537742, 11538015, 14873071, 17396660, 22391483, 24263048, 24862236, 25621962, 26612376, 26679989, 26755288, 29203860, 46488006, 49681218, 49698524, 49834379, 50110885, 50110886, 57405324, 57649481, 79908771, 87560451, 92124957, 92125361, 92710903, 99301744, 99437070, 103914249, 104179191, 104644865, 108667034, 124636730, 124757138, 125163942, 126631402, 131480746, 135692091, 136367381, 136368092, 140607255, 144115625, 162249932, 163614422, 166223153, 176484289
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| ChEBI ID |
CHEBI:223316
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| SuperDrug ATC ID |
P01BE01
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| SuperDrug CAS ID |
cas=063968649
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -7.443; p = 0.015). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -8.156; p = 0.038). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -3.289; p = 0.01). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -9.517; p = 0.008). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -8.013; p = 0.013). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -7.334; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -8.742; p = 0.013). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -8.731; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -8.281; p = 0.016). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -8.195; p = 0.015). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -2.249; p = 0.029). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -7.546; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -7.601; p = 0.017). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -3.379; p = 0.004). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -1.543; p = 0.006). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -1.146; p = 0.041). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -1.786; p = 0.004). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -1.363; p = 0.007). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -1.615; p = 0.009). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -5.311; p = 0.004). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -9.345; p = 0.01). | |||
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Studied Microbe: Bacteroides WH2
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides WH2 (log2FC = -1.966; p = 0.004). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -3.467; p = 0.003). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Odoribacter splanchnicus (log2FC = -8.445; p = 0.025). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -5.379; p = 0.005). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -4.464; p = 0.019). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -3.405; p = 0.005). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Pretovella copri DSM 18205 (log2FC = -8.526; p = 0.006). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -7.453; p = 0.002). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -7.901; p = 0.006). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -7.874; p = 0.005). | |||
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Studied Microbe: Bifidobacterium ruminantium
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bifidobacterium ruminantium (log2FC = -8.006; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens ATCC25986
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -8.876; p = 0.009). | |||
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Studied Microbe: Collinsella intestinalis DSM 13280
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Collinsella intestinalis DSM 13280 (log2FC = -7.314; p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -6.686; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Edwardsiella tarda ATCC 23685
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -8.3; p = 0.005). | |||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -8.442; p = 0.009). | |||
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Studied Microbe: Escherichia coli BW25113
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Escherichia coli BW25113 (log2FC = -7.966; p = 0.011). | |||
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Studied Microbe: Proteus penneri ATCC 35198
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Proteus penneri ATCC 35198 (log2FC = -8.412; p = 0.01). | |||
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Studied Microbe: Providencia alcalifaciens DSM 30120
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Providencia alcalifaciens DSM 30120 (log2FC = -7.505; p = 0.004). | |||
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Studied Microbe: Providencia rettgeri DSM 1131
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Providencia rettgeri DSM 1131 (log2FC = -7.849; p = 0.016). | |||
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Studied Microbe: Providencia stuartii ATCC 25827
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -8.385; p = 0.009). | |||
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Studied Microbe: Salmonella typhimurium LT2
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Salmonella typhimurium LT2 (log2FC = -6.861; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium ramosum DSM 1402
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -7.873; p = 0.008). | |||
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Studied Microbe: Clostridium spiroforme DSM1552
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -8.391; p = 0.007). | |||
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Studied Microbe: Eubacterium biforme DSM 3989
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -7.416; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Anaerostipes sp. (log2FC = -8.374; p = 0.01). | |||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -8.371; p = 0.009). | |||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -7.844; p = 0.02). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Blautia hansenii DSM20583 (log2FC = -7.812; p = 0.018). | |||
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Studied Microbe: Blautia luti DSM 14534
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Blautia luti DSM 14534 (log2FC = -7.645; p = 0.006). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -7.344; p = 0.008). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -7.546; p = 0.008). | |||
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Studied Microbe: Clostridium difficile 120
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium difficile 120 (log2FC = -7.173; p = 0.008). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -8.183; p = 0.027). | |||
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Studied Microbe: Clostridium scindens ATCC 35704
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -8.355; p = 0.003). | |||
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Studied Microbe: Clostridium sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium sp. (log2FC = -7.563; p = 0.008). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -7.776; p = 0.012). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -8.065; p = 0.005). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -8.173; p = 0.014). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -8.363; p = 0.006). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -8.558; p = 0.003). | |||
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Studied Microbe: Eubacterium hallii DSM3353
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Eubacterium hallii DSM3353 (log2FC = -7.316; p = 0.005). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -7.581; p = 0.012). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -8.584; p = 0.006). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Roseburia intestinalis L1-82 (log2FC = -7.733; p = 0.007). | |||
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Studied Microbe: Ruminococcus gnavus ATCC 29149
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| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -7.397; p = 0.004). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -8.429; p = 0.015). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -7.784; p = 0.004). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -7.699; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecalis V583
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Enterococcus faecalis V583 (log2FC = -7.296; p = 0.007). | |||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -1.27; p = 0.018). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -8.458; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -7.571; p = 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Artemisinin can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -6.893; p = 0.008). | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides uniformis
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Artemisinin (adjusted p-values: 8.91E-04). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [1] |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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