Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R3FP
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| Drug Name |
Tenofovir disoproxil fumarate
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| Synonyms |
Bis-POC-PMPA; GSK548470; PMPA-oral; Tenofovir DF; Tenozet; Viread
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Approved | [1] | |
| Therapeutic Class |
Antiinfective Agents
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| Structure |
 |
Download2D MOL
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| Formula |
C23H34N5O14P
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| Canonical SMILES |
CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C.C(=CC(=O)O)C(=O)O
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| InChI |
1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1
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| InChIKey |
VCMJCVGFSROFHV-WZGZYPNHSA-N
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| CAS Number |
CAS 202138-50-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:63718
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| ADReCS Drug ID | BADD_D02156 | |||
| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Tenofovir disoproxil fumarate: a nucleotide reverse transcriptase inhibitor for the treatment of HIV infection. Clin Ther. 2002 Oct;24(10):1515-48. | |||
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