Drug General Information
Drug ID D0R3FP
Drug Name Tenofovir disoproxil fumarate
Synonyms Bis-POC-PMPA; GSK548470; PMPA-oral; Tenofovir DF; Tenozet; Viread
Drug Type Small molecular drug
Therapeutic Class Antiinfective Agents
Structure D0R3FP
Drug Resistance Mutations
Target Name HBV Reverse transcriptase Target Info
Uniprot ID DPOL_HBVB5(347-690)
Species Hepatitis B virus genotype B (HBV-B)
Reference Sequence EDWGPCTEHGEHRIRTPRTPARVTGGVFLVDKNPHNTTESRLVVDFSQFSRGNTRVSWPK
FAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSNSR
IINNQHRTMQNLHNSCSRNLYVSLMLLYKTYGRKLHLYSHPIILGFRKIPMGVGLSPFLL
AQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLYAAVTNFLLSLGIHLNPHKT
KRWGYSLNFMGYVIGSWGTLPQEHIVQKIKMCFRKLPVNRPIDWKVCQRIVGLLGFAAPF
TQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQYLNLYPVARQ [Hepatitis B vi
rus genotype B (HBV-B)]
Targeted Disease HBV infection
Drug Resistance Mutations
Mutation info Missense: A194T [1]
Mutation Frequency 2 out of 317 patients
References
REF 1 [Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology]. Zhonghua Gan Zang Bing Za Zhi. 2016 Jan;24(1):36-9.

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