Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0P5YR
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| Former ID |
DNC009040
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| Drug Name |
[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine
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| Synonyms |
MAO; 5'-DEOXY-5'-[N-METHYL-N-(2-AMINOOXYETHYL) AMINO]ADENOSINE; 112621-39-3; AC1L9JAL; MAOEA, 5; SCHEMBL956861; Adenosine,5'-[[2-(aminooxy)ethyl]methylamino]-5'-deoxy- (9CI); CHEMBL461780; CTK4A7898; BDBM28431; AKOS030589585; 5'-[(2-Aminooxyethyl)methylamino]-5'-deoxyadenosine; 5'-{[2-(aminooxy)ethyl](methyl)amino}-5'-deoxyadenosine; (2R,3S,4R,5R)-2-[[2-aminooxyethyl(methyl)amino]methyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H21N7O4
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| Canonical SMILES |
CN(CCON)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
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| InChI |
1S/C13H21N7O4/c1-19(2-3-23-15)4-7-9(21)10(22)13(24-7)20-6-18-8-11(14)16-5-17-12(8)20/h5-7,9-10,13,21-22H,2-4,15H2,1H3,(H2,14,16,17)/t7-,9-,10-,13-/m1/s1
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| InChIKey |
PPIPUCUVJJZYEK-QYVSTXNMSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | S-adenosylmethionine decarboxylase proenzyme (AMD1) | Target Info | Inhibitor | [1] |
| BioCyc | Methionine salvage cycle III | |||
| Spermine biosynthesis | ||||
| Spermidine biosynthesis | ||||
| KEGG Pathway | Cysteine and methionine metabolism | |||
| Arginine and proline metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Methionine Metabolism | ||||
| WikiPathways | Metabolism of amino acids and derivatives | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407. | |||
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