Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P4DJ
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| Former ID |
DAP001054
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| Drug Name |
Somatropin recombinant
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| Synonyms |
Genotropin (TN); Humatrope (TN); Norditropin (TN); Nutropin (TN); Saizen (TN)
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| Indication | Growth hormone deficiency [ICD-11: 5A61.3] | Approved | [1] | |
| Therapeutic Class |
Hormone Replacement Agents
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| Company |
Pfizer Pharmaceuticals
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Growth hormone receptor (GHR) | Target Info | Binder | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Neuroactive ligand-receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Pathway Interaction Database | Notch-mediated HES/HEY network | |||
| Reactome | Prolactin receptor signaling | |||
| Growth hormone receptor signaling | ||||
| WikiPathways | Endochondral Ossification | |||
| Prolactin receptor signaling | ||||
| Growth hormone receptor signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Cost-utility of somatropin (rDNA origin) in the treatment of growth hormone deficiency in children. Curr Med Res Opin. 2006 Feb;22(2):351-7. | |||
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