Drug Information
Drug General Information | Top | |||
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Drug ID |
D0O1ZI
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Former ID |
DCL001156
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Drug Name |
AZD8329
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Synonyms |
AZD-8329; AZD 8329; UNII-5B38CV1212; 1048668-70-7; CHEMBL2177609; 5B38CV1212; 4-[4-(2-Adamantylcarbamoyl)-5-Tert-Butyl-Pyrazol-1-Yl]benzoic Acid; AZD8329; XWBXJBSVYVJAMZ-UHFFFAOYSA-N; SCHEMBL617351; GTPL7715; BDBM50399335; 4-(4-(Adamant-2-ylcarbamoyl)-5-tert-butylpyrazol-1-yl)benzoic acid; Benzoic acid, 4-(5-(1,1-dimethylethyl)-4-((tricyclo(3.3.1.13,7)dec-2-ylamino)carbonyl)-1H-pyrazol-1-yl)-; 4-[4-(2-adamantylcarbamoyl)-5-tertbutyl-pyrazol-1-yl]benzoic acid; 4-[4-(2-adamantylcarbamoyl)-5-tert-butylpyrazol-1-yl]benzoic ac
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Drug Type |
Small molecular drug
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Indication | Diabetic complication [ICD-11: 5A2Y] | Phase 1 | [1], [2] | |
Obesity [ICD-11: 5B81; ICD-10: E66] | Phase 1 | [1], [2] | ||
Company |
AstraZeneca
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Structure |
Download2D MOL
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Formula |
C25H31N3O3
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Canonical SMILES |
CC(C)(C)C1=C(C=NN1C2=CC=C(C=C2)C(=O)O)C(=O)NC3C4CC5CC(C4)CC3C5
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InChI |
1S/C25H31N3O3/c1-25(2,3)22-20(13-26-28(22)19-6-4-16(5-7-19)24(30)31)23(29)27-21-17-9-14-8-15(11-17)12-18(21)10-14/h4-7,13-15,17-18,21H,8-12H2,1-3H3,(H,27,29)(H,30,31)
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InChIKey |
XWBXJBSVYVJAMZ-UHFFFAOYSA-N
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CAS Number |
CAS 1048668-70-7
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) | Target Info | Inhibitor | [2] |
KEGG Pathway | Steroid hormone biosynthesis | |||
Metabolism of xenobiotics by cytochrome P450 | ||||
Metabolic pathways | ||||
Chemical carcinogenesis | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
FSH Signaling Pathway | ||||
Pathwhiz Pathway | Steroidogenesis | |||
Reactome | Glucocorticoid biosynthesis | |||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
Metabolism of steroid hormones and vitamin D | ||||
Glucocorticoid & Mineralcorticoid Metabolism |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7715). | |||
REF 2 | Clinical pipeline report, company report or official report of AstraZeneca (2011). |
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