Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NM0G
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| Former ID |
DNC010551
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| Drug Name |
GSK-3787
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| Synonyms |
GSK3787; 188591-46-0; GSK 3787; GSK-3787; 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide; CHEMBL598608; 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide; 4-chloro-N-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfonylethyl]benzamide; Benzamide, 4-chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-; Maybridge3_000547; AC1MCTIO; C15H12ClF3N2O3S; MLS006012025; SCHEMBL14968834; CTK8E8261; KS-00000XJC; AOB6285; QCR-146; EX-A704; DTXSID00384175; MolPort-002-892-395; HMS1432I19
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C15H12ClF3N2O3S
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| Canonical SMILES |
C1=CC(=CC=C1C(=O)NCCS(=O)(=O)C2=NC=C(C=C2)C(F)(F)F)Cl
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| InChI |
1S/C15H12ClF3N2O3S/c16-12-4-1-10(2-5-12)14(22)20-7-8-25(23,24)13-6-3-11(9-21-13)15(17,18)19/h1-6,9H,7-8H2,(H,20,22)
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| InChIKey |
JFUIMTGOQCQTPF-UHFFFAOYSA-N
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| CAS Number |
CAS 188591-46-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Peroxisome proliferator-activated receptor delta (PPARD) | Target Info | Inhibitor | [1] |
| KEGG Pathway | PPAR signaling pathway | |||
| Wnt signaling pathway | ||||
| Pathways in cancer | ||||
| Acute myeloid leukemia | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Wnt signaling pathway | |||
| Pathway Interaction Database | Presenilin action in Notch and Wnt signaling | |||
| RXR and RAR heterodimerization with other nuclear receptor | ||||
| Reactome | Import of palmitoyl-CoA into the mitochondrial matrix | |||
| Regulation of pyruvate dehydrogenase (PDH) complex | ||||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Wnt Signaling Pathway and Pluripotency | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Vitamin D Receptor Pathway | ||||
| Ectoderm Differentiation | ||||
| Adipogenesis | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversibl... J Med Chem. 2010 Feb 25;53(4):1857-61. | |||
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