Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M9TG
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| Drug Name |
Phthalazine derivative 3
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| Synonyms |
PMID27841036-Compound-19
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| Drug Type |
Small molecular drug
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| Company |
Shanghai Institute of Materia Medica
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H14F4N6O3
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| Canonical SMILES |
C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C3=C(C=CC(=C3)OC4=NNC(=O)C5=CC=CC=C54)F
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| InChI |
1S/C21H14F4N6O3/c22-15-6-5-11(34-18-13-4-2-1-3-12(13)17(32)27-28-18)9-14(15)19(33)30-7-8-31-16(10-30)26-29-20(31)21(23,24)25/h1-6,9H,7-8,10H2,(H,27,32)
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| InChIKey |
MZFDEPWODAICMP-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Poly [ADP-ribose] polymerase 1 (PARP1) | Target's Patent Info | [1] | |
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. | |||
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