Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L5MF
|
|||
| Former ID |
DIB005198
|
|||
| Drug Name |
PYRAZOLOACRIDINE
|
|||
| Synonyms |
PD-115934; 2-[3-(Dimethylamino)propyl]-9-methoxy-5-nitro-2,6-dihydropyrazolo[3,4,5-kl]acridine; 9-Methoxy-N,N-dimethyl-5-nitro-2,6-dihydropyrazolo[3,4,5-kl]acridine-2-propanamine
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Colorectal cancer [ICD-11: 2B91.Z] | Phase 2 | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C19H21N5O3
|
|||
| Canonical SMILES |
CN(C)CCCN1C2=C3C(=C(C=C2)[N+](=O)[O-])NC4=C(C3=N1)C=C(C=C4)OC
|
|||
| InChI |
1S/C19H21N5O3/c1-22(2)9-4-10-23-15-7-8-16(24(25)26)19-17(15)18(21-23)13-11-12(27-3)5-6-14(13)20-19/h5-8,11,20H,4,9-10H2,1-3H3
|
|||
| InChIKey |
HZCWPKGYTCJSEB-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 99009-20-8
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
493329, 798788, 5106348, 8137501, 11407763, 11413001, 11447219, 14901736, 37391548, 39377936, 47440973, 47811428, 50029893, 53787501, 57361365, 79749756, 103344686, 118197663, 124633467, 128134067, 128134068, 134959725, 135072101, 137560245, 140349375, 142916067, 198988612, 227137524, 232082314, 241338284, 248250635, 249923342
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00003802) Pyrazoloacridine in Treating Patients With Metastatic Skin or Eye Melanoma. U.S. National Institutes of Health. | |||
| REF 2 | Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II. Clin Cancer Res. 1998 Mar;4(3):683-91. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.