Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K6UK
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| Former ID |
DNC001265
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| Drug Name |
Saframycin A
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| Synonyms |
AC1MHXXG
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C29H30N4O8
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| Canonical SMILES |
CC1=C(C(=O)C2=C(C1=O)CC3C4C5=C(CC(N4C)C(N3C2CNC(=O)C(=O)C)C#N)C(=O)C(=C(C5=O)OC)C)OC
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| InChI |
1S/C29H30N4O8/c1-11-23(35)14-8-17-22-21-15(24(36)12(2)28(41-6)26(21)38)7-16(32(22)4)18(9-30)33(17)19(10-31-29(39)13(3)34)20(14)25(37)27(11)40-5/h16-19,22H,7-8,10H2,1-6H3,(H,31,39)/t16-,17-,18-,19-,22-/m0/s1
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| InChIKey |
JNEGMBHBUAJRSX-SHUHUVMISA-N
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| CAS Number |
CAS 66082-27-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | Target Info | Binder | [1] |
| BioCyc | Superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle | |||
| Gluconeogenesis | ||||
| NADH repair | ||||
| Glycolysis | ||||
| KEGG Pathway | Glycolysis / Gluconeogenesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Carbon metabolism | ||||
| Biosynthesis of amino acids | ||||
| HIF-1 signaling pathway | ||||
| Alzheimer's disease | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| TSH Signaling Pathway | ||||
| Panther Pathway | Glycolysis | |||
| Huntington disease | ||||
| Pathwhiz Pathway | Glycerol Phosphate Shuttle | |||
| Glycolysis | ||||
| Gluconeogenesis | ||||
| Mitochondrial Electron Transport Chain | ||||
| Warburg Effect | ||||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| Reactome | Glycolysis | |||
| Gluconeogenesis | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Glycolysis and Gluconeogenesis | ||||
| Alzheimers Disease | ||||
| Cori Cycle | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification of GAPDH as a protein target of the saframycin antiproliferative agents. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5862-6. | |||
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