Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K1SR
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| Former ID |
DIB013798
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| Drug Name |
PH-794428
|
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| Synonyms |
PHA-794428
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|
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| Indication | Growth hormone deficiency [ICD-11: 5A61.3] | Phase 2 | [1] | |
| Company |
Pfizer
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Growth hormone receptor (GHR) | Target Info | Modulator | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Neuroactive ligand-receptor interaction | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Pathway Interaction Database | Notch-mediated HES/HEY network | |||
| Reactome | Prolactin receptor signaling | |||
| Growth hormone receptor signaling | ||||
| WikiPathways | Endochondral Ossification | |||
| Prolactin receptor signaling | ||||
| Growth hormone receptor signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00308464) A Study To Evaluate The Dose Response And Safety Of PHA-794428 In Adults With Growth Hormone Deficiency. U.S. National Institutes of Health. | |||
| REF 2 | PEGylation of somatropin (recombinant human growth hormone): impact on its clearance in humans.Xenobiotica.2008 Oct;38(10):1340-51. | |||
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