Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J4GY
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| Drug Name |
Dihydropyrido phthalazinone derivative 2
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| Synonyms |
PMID27841036-Compound-22
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H15F2N7O
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| Canonical SMILES |
CN1C(=NC=N1)C2C(NNC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
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| InChI |
1S/C19H15F2N7O/c1-28-18(22-8-23-28)15-16(9-2-4-10(20)5-3-9)25-24-13-7-11(21)6-12-14(13)17(15)26-27-19(12)29/h2-8,15-16,24-25H,1H3,(H,27,29)
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| InChIKey |
VGIBCJTZZYLWON-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Poly [ADP-ribose] polymerase 1 (PARP1) | Target's Patent Info | [1] | |
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. | |||
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