Drug Information
Drug General Information | Top | |||
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Drug ID |
D0I7IF
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Former ID |
DNC007870
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Drug Name |
6-bromo-5-phenylpyrimidine-2,4(1H,3H)-dione
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Synonyms |
CHEMBL235666; BDBM20076; 6-Bromo-5-phenylpyrimidine-2,4(1H,3H)-dione, 23
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C10H7BrN2O2
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Canonical SMILES |
C1=CC=C(C=C1)C2=C(NC(=O)NC2=O)Br
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InChI |
1S/C10H7BrN2O2/c11-8-7(6-4-2-1-3-5-6)9(14)13-10(15)12-8/h1-5H,(H2,12,13,14,15)
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InChIKey |
XSEDFSJHHTXVPL-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Thymidine phosphorylase (TYMP) | Target Info | Inhibitor | [1] |
BioCyc | Pyrimidine deoxyribonucleosides degradation | |||
KEGG Pathway | Pyrimidine metabolism | |||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Bladder cancer | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Pathwhiz Pathway | Pyrimidine Metabolism | |||
WikiPathways | Bladder Cancer | |||
Metabolism of nucleotides | ||||
Fluoropyrimidine Activity |
References | Top | |||
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REF 1 | Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. |
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