Drug Information
Drug General Information | Top | |||
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Drug ID |
D0I2GK
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Former ID |
DNC006283
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Drug Name |
Detrothyronine
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Synonyms |
DT-3; 3,5,3'-Triiodo-D-thyronine; CHEMBL557; UNII-46XII7C16X; 46XII7C16X; Detrothyronin; dt 3; 5714/8/9; Dextro-3:5:3'-triiodothyronine; Detrothyroninum; Detrotironina; D-Trijodthyronin; DEXTROTHYRONINE; Triiodothyronine, D-; Detrothyronine [INN]; AC1L2FR4; SCHEMBL8301; AC1Q5R0T; DT 3 (hormone) (VAN); Detrotironina [INN-Spanish]; Detrothyroninum [INN-Latin]; DT3 (VAN); D-3,5,3'-Triiodothyronine; CTK4G9296; (2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid; SKF D 2623
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C15H12I3NO4
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Canonical SMILES |
C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O
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InChI |
1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m1/s1
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InChIKey |
AUYYCJSJGJYCDS-GFCCVEGCSA-N
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CAS Number |
CAS 5714-08-9
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Thyroid hormone receptor alpha (THRA) | Target Info | Inhibitor | [1] |
Thyroid hormone receptor beta (THRB) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Thyroid hormone signaling pathway | ||||
Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
Reactome | Nuclear Receptor transcription pathway | |||
WikiPathways | SIDS Susceptibility Pathways | |||
Hematopoietic Stem Cell Differentiation | ||||
Nuclear Receptors | ||||
Endochondral Ossification |
References | Top | |||
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REF 1 | Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1240-4. |
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