Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F7NQ
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| Former ID |
DAP000814
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| Drug Name |
Flumethasone Pivalate
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| Synonyms |
Locacorten; Locorten; Lorinden; Flumetasone pivalate; Flumethasone pivalate (USP); KS-1138; Locorten (TN); Flumetasone pivalate (JAN/BAN); Lpha.-methylpregna-1,4-diene-3,20-dione 21-pivalate; [2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate; 6,9-Difluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pivalate; 6.Alpha.,9-Difluoro-11.beta.,17,21-trihydroxy-16.a; 6.Alpha.,9.alpha.-Difluoro-16.alpha.-methylprednisolone 21-pivalate; 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate); 6alpha,9-difluoro-11beta,17-dihydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate
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| Drug Type |
Small molecular drug
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| Indication | Contact dermatitis [ICD-11: EK0Z; ICD-9: 692] | Approved | [1], [2] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
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Download2D MOL |
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| Formula |
C27H36F2O6
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| Canonical SMILES |
CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C(C)(C)C)O)C)O)F)C)F
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| InChI |
1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1
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| InChIKey |
JWRMHDSINXPDHB-OJAGFMMFSA-N
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| CAS Number |
CAS 2002-29-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
222338, 855730, 7848527, 10299452, 15455637, 24894735, 25819967, 36887111, 46505121, 56352898, 56423133, 57404579, 71825573, 80419023, 92719765, 103770860, 104631069, 124799724, 124886795, 126620550, 126653105, 134223931, 134338095, 134983472, 135867381, 137008618, 139999917, 142971015, 152104260, 160964008, 164810392, 175612214, 178103654, 179423754, 187072275, 196106201, 198948936, 226398407, 252160856, 252349886, 252401851, 252543030
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| ChEBI ID |
CHEBI:31620
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| SuperDrug ATC ID |
D07AB03; D07XB01
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Steroid hormone receptor ERR (ESRR) | Target Info | Modulator | [3] |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7075). | |||
| REF 2 | Drug information of Flumethasone Pivalate, 2008. eduDrugs. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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