Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F3PU
|
|||
| Former ID |
DCL000535
|
|||
| Drug Name |
Iboctadekin + Doxil
|
|||
| Drug Type |
Combination drug
|
|||
| Indication | Ovarian cancer [ICD-11: 2C73; ICD-10: C56; ICD-9: 183] | Phase 1 | [1], [2] | |
| Company |
GSK
|
|||
| Structure |
 |
|||
| Canonical SMILES |
failed
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Inhibitor | [3] |
| Interleukin-18 (IL18) | Target Info | Modulator | [3] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| NOD-like receptor signaling pathway | ||||
| Cytosolic DNA-sensing pathway | ||||
| Salmonella infection | ||||
| Legionellosis | ||||
| African trypanosomiasis | ||||
| Malaria | ||||
| Tuberculosis | ||||
| Influenza A | ||||
| Inflammatory bowel disease (IBD) | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Panther Pathway | Interleukin signaling pathway | |||
| Toll receptor signaling pathway | ||||
| Pathway Interaction Database | IL27-mediated signaling events | |||
| IL12-mediated signaling events | ||||
| IL23-mediated signaling events | ||||
| Cellular roles of Anthrax toxin | ||||
| IL12 signaling mediated by STAT4 | ||||
| Reactome | Interleukin-1 processing | |||
| WikiPathways | Hypertrophy Model | |||
| IL1 and megakaryotyces in obesity | ||||
| Corticotropin-releasing hormone | ||||
| NOD pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of GlaxoSmithKline. | |||
| REF 2 | ClinicalTrials.gov (NCT00659178) Combination Study Of SB-485232 (Interleukin 18) And Doxil For Advanced Stage Epithelial Ovarian Cancer. U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). | |||
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