Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F2KX
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| Former ID |
DIB005761
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| Drug Name |
Granotapide
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| Synonyms |
JTT-130
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| Drug Type |
Small molecular drug
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| Indication | Hyperlipidaemia [ICD-11: 5C80; ICD-10: E78.5] | Phase 2 | [1] | |
| Company |
Japan Tobacco Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C39H37F3N2O8
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| Canonical SMILES |
CCOC(=O)C(COC(=O)CC1=CC(=C(C=C1)NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)C(=O)N(C)C)(C4=CC=CC=C4)C(=O)OCC
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| InChI |
1S/C39H37F3N2O8/c1-5-50-36(48)38(37(49)51-6-2,27-12-8-7-9-13-27)24-52-33(45)23-25-16-21-32(31(22-25)35(47)44(3)4)43-34(46)30-15-11-10-14-29(30)26-17-19-28(20-18-26)39(40,41)42/h7-22H,5-6,23-24H2,1-4H3,(H,43,46)
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| InChIKey |
FPUQGCOBYOXAED-UHFFFAOYSA-N
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| CAS Number |
CAS 594842-13-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Microsomal triglyceride transfer protein (MTTP) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Fat digestion and absorption | |||
| Reactome | Chylomicron-mediated lipid transport | |||
| WikiPathways | Statin Pathway | |||
| Lipid digestion, mobilization, and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00929539) Safety and Efficacy Study of JTT-130 in Obese Type 2 Diabetic Patients. U.S. National Institutes of Health. | |||
| REF 2 | JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner. J Pharmacol Exp Ther. 2011 Mar;336(3):850-6. | |||
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