Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0EE5S
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| Drug Name |
2-pyrazinone derivative 7
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| Synonyms |
PMID26118988-Compound-34
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C25H21F3N6O2
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| Canonical SMILES |
CC1=C(N=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)N)C3=NC(CN3C4=CC=C(C=C4)C#N)(C)C
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| InChI |
1S/C25H21F3N6O2/c1-14-19(22-32-24(2,3)13-33(22)17-9-7-15(12-29)8-10-17)31-20(21(30)35)23(36)34(14)18-6-4-5-16(11-18)25(26,27)28/h4-11H,13H2,1-3H3,(H2,30,35)
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| InChIKey |
CMHWRRKHSAWOMT-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neutrophil elastase (NE) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Neutrophil elastase (NE) | Target's Patent Info | [1] | |
| KEGG Pathway | Transcriptional misregulation in cancer | |||
| Systemic lupus erythematosus | ||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||
| C-MYB transcription factor network | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||
| Human Complement System | ||||
| Degradation of collagen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. | |||
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