Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E2WX
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| Former ID |
DNC000083
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| Drug Name |
5-Fluoro orotate
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| Synonyms |
5-Fluoroorotic acid; 703-95-7; 5-Fluoroorotate; 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid; Fluoroorotic acid; Orotic acid, 5-fluoro-; 5-FOA; 5-Fluoro orotic acid; NSC 31712; ENT-26398; Ro 2-9945; 5-Fluorouracil-4-carboxylic acid; UNII-7IA9OUC93E; WR 152520; 5-Fluoroorotic acid (VAN); MLS000737636; EINECS 211-876-0; 4-Pyrimidinecarboxylic acid, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-; 7IA9OUC93E; AI3-26398; FOA; 5-Fluorouracil-6-carboxylic Acid; SEHFUALWMUWDKS-UHFFFAOYSA-N
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C5H3FN2O4
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| Canonical SMILES |
C1(=C(NC(=O)NC1=O)C(=O)O)F
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| InChI |
1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12)
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| InChIKey |
SEHFUALWMUWDKS-UHFFFAOYSA-N
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| CAS Number |
CAS 703-95-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
90504, 3153098, 5475000, 5649795, 8193186, 15120499, 15237848, 24423710, 26665898, 29200902, 43126167, 49747497, 50035842, 57317513, 79239090, 85086136, 85245872, 87570153, 91613269, 103145057, 104248978, 104345707, 117542376, 118314454, 124441995, 124953268, 125130898, 125356484, 126632763, 126658991, 126690013, 127324882, 127324883, 129223725, 134339616, 135026731, 136992188, 137023646, 143438861, 143551517, 144223859, 160813742, 162092756, 162178809, 163089708, 163373396, 164849284, 165235677, 165246065, 171580051
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| SuperDrug ATC ID |
L01BC02
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| SuperDrug CAS ID |
cas=000051218
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium Dihydroorotase (Malaria dho) | Target Info | Inhibitor | [1] |
| Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. | |||
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